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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-987

Struhl, G; Basler, K (1993). Organizing activity of wingless protein in Drosophila. Cell, 72(4):527-540.



The adult appendages of Drosophila are formed from imaginal discs, sheets of epithelial cells that proliferate during larval development and differentiate during metamorphosis. wingless (wg, DWnt-1) protein, a putative signaling molecule, is expressed only in prospective ventral cells in each of the leg discs. To test the role of wg, we have generated randomly positioned clones of cells that express wg protein constitutively. Clones that arise in the prospective ventral portions of the leg discs develop normally. In contrast, dorsally situated clones give rise to ventrolateral patterns and exert a ventralizing influence on neighboring wild-type tissue. We propose that wg protein organizes leg pattern along the dorsoventral axis by conferring ventral positional information within the disc.

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Date:26 February 1993
Deposited On:11 Feb 2008 12:19
Last Modified:02 Dec 2013 11:21
Publisher DOI:10.1016/0092-8674(93)90072-X
PubMed ID:8440019
Citations:Web of Science®. Times Cited: 584
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