UZH-Logo

Maintenance Infos

Potential cellular receptors involved in hepatitis C virus entry into cells


Favre, D M; Muellhaupt, B (2005). Potential cellular receptors involved in hepatitis C virus entry into cells. Lipids in Health and Disease, 4:9.

Abstract

Hepatitis C virus (HCV) infects hepatocytes and leads to permanent, severe liver damage. Since the genomic sequence of HCV was determined, progress has been made towards understanding the functions of the HCV-encoded proteins and identifying the cellular receptor(s) responsible for adsorption and penetration of the virus particle into the target cells. Several cellular receptors for HCV have been proposed, all of which are associated with lipid and lipoprotein metabolism. This article reviews the cellular receptors for HCV and suggests a general model for HCV entry into cells, in which lipoproteins play a crucial role.

Hepatitis C virus (HCV) infects hepatocytes and leads to permanent, severe liver damage. Since the genomic sequence of HCV was determined, progress has been made towards understanding the functions of the HCV-encoded proteins and identifying the cellular receptor(s) responsible for adsorption and penetration of the virus particle into the target cells. Several cellular receptors for HCV have been proposed, all of which are associated with lipid and lipoprotein metabolism. This article reviews the cellular receptors for HCV and suggests a general model for HCV entry into cells, in which lipoproteins play a crucial role.

Citations

Altmetrics

Downloads

49 downloads since deposited on 11 Feb 2008
8 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Gastroenterology and Hepatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2005
Deposited On:11 Feb 2008 12:12
Last Modified:05 Apr 2016 12:12
Publisher:BioMed Central
ISSN:1476-511X
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1186/1476-511X-4-9
Official URL:http://www.lipidworld.com/content/pdf/1476-511X-4-9.pdf
PubMed ID:15836798
Permanent URL: http://doi.org/10.5167/uzh-99

Download

[img]
Preview
Content: Published Version
Filetype: PDF
Size: 348kB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations