UZH-Logo

Maintenance Infos

Artificial bacterial flagella functionalized with temperature-sensitive liposomes for controlled release


Qiu, Famin; Mhanna, Rami; Zhang, Li; Ding, Yun; Fujita, Satoshi; Nelson, Bradley J (2014). Artificial bacterial flagella functionalized with temperature-sensitive liposomes for controlled release. Sensors and Actuators B: Chemical, 196:676-681.

Abstract

Inspired by flagellar propulsion of bacteria such as E. coli, artificial bacterial flagella (ABFs) are magnetic swimming microrobots with helical shapes. ABFs are capable of performing precise three-dimensional (3D) navigation in fluids under low-strength rotating magnetic fields making them attractive tools for targeted drug delivery. Further biomedical functionalization of these swimming microrobots is essential to enhance their biological and medical performances. We report the successful functionalization of titanium-coated ABFs with temperature-sensitive dipalmitoylphosphatidylcholine (DPPC)-based liposomes, known as “smart” drug carriers. Liposome coating on the surface of ABFs was confirmed using quartz crystal microbalance with dissipation monitoring (QCM-D) and fluorescent probes. The functionalized ABFs (f-ABFs) showed the ability to incorporate both hydrophilic and hydrophobic drugs. Finally, thermally triggered release of calcein (a common drug analog) from f-ABFs was demonstrated. These f-ABFs have the potential to be used in targeted and triggered drug delivery, microfluidic devices and biosensing.

Abstract

Inspired by flagellar propulsion of bacteria such as E. coli, artificial bacterial flagella (ABFs) are magnetic swimming microrobots with helical shapes. ABFs are capable of performing precise three-dimensional (3D) navigation in fluids under low-strength rotating magnetic fields making them attractive tools for targeted drug delivery. Further biomedical functionalization of these swimming microrobots is essential to enhance their biological and medical performances. We report the successful functionalization of titanium-coated ABFs with temperature-sensitive dipalmitoylphosphatidylcholine (DPPC)-based liposomes, known as “smart” drug carriers. Liposome coating on the surface of ABFs was confirmed using quartz crystal microbalance with dissipation monitoring (QCM-D) and fluorescent probes. The functionalized ABFs (f-ABFs) showed the ability to incorporate both hydrophilic and hydrophobic drugs. Finally, thermally triggered release of calcein (a common drug analog) from f-ABFs was demonstrated. These f-ABFs have the potential to be used in targeted and triggered drug delivery, microfluidic devices and biosensing.

Citations

14 citations in Web of Science®
14 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:2014
Deposited On:03 Oct 2014 16:03
Last Modified:05 Apr 2016 18:24
Publisher:Elsevier
ISSN:0925-4005
Publisher DOI:https://doi.org/10.1016/j.snb.2014.01.099

Download

Full text not available from this repository.
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations