Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-9928

Ferrantelli, F; Buckley, K A; Rasmussen, R A; Chalmers, A; Wang, T; Li, P L; Williams, A L; Hofmann-Lehmann, R; Montefiori, D C; Cavacini, L A; Katinger, H; Stiegler, G; Anderson, D C; McClure, H M; Ruprecht, R M (2007). Time dependence of protective post-exposure prophylaxis with human monoclonal antibodies against pathogenic SHIV challenge in newborn macaques. Virology, 358(1):69-78.

[img] PDF - Registered users only
1MB

View at publisher

Abstract

In a primate model of postnatal virus transmission, we have previously shown that 1 h post-exposure prophylaxis (PEP) with a triple combination of neutralizing monoclonal antibodies (nmAbs) conferred sterilizing protection to neonatal macaques against oral challenge with pathogenic simian-human immunodeficiency virus (SHIV). Here, we show that nmAbs can also partially protect SHIV-exposed newborn macaques against infection or disease, when given as 12 or 24 h PEP, respectively. This work delineates the potential and the limits of passive immunoprophylaxis with nmAbs. Even though 24 h PEP with nmAbs did not provide sterilizing immunity to neonatal monkeys, it contained viremia and protected infants from acute disease. Taken together with our results from other PEP studies, these data show that the success of passive immunization depends on the nmAb potency/dose and the time window between virus exposure and start of immunotherapy.

Citations

27 citations in Web of Science®
26 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 24 Mar 2009
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
DDC:570 Life sciences; biology
630 Agriculture
Language:English
Date:2007
Deposited On:24 Mar 2009 14:26
Last Modified:30 Oct 2014 16:04
Publisher:Academic Press
ISSN:0042-6822
Publisher DOI:10.1016/j.virol.2006.07.056
PubMed ID:16996554

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page