Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-996
Zecca, M; Basler, K; Struhl, G (1996). Direct and long-range action of a wingless morphogen gradient. Cell, 87(5):833-844.
View at publisher
Wingless (Wg), a founding member of the Wingless/Int-1 (Wnt) family of secreted proteins, acts as a short-range inducer and as a long-range organizer during Drosophila development. Here, we determine the consequences of ectopically expressing (i) a wild-type form of Wg, (ii) a membrane-tethered form of Wg, and (iii) a constitutively active form of the cytosolic protein Armadillo (Arm), which normally acts to transduce Wg, and we compare them with the effects of removing endogenous Wg or Arm activity. Our results indicate that wild-type Wg acts at long range, up-regulating the transcription of particular target genes as a function of concentration and distance from secreting cells. In contrast, tethered Wg and Arm have only short-range or autonomous effects, respectively, on the transcription of these genes. We interpret these findings as evidence that Wg can act directly and at long range as a gradient morphogen during normal development.
73 downloads since deposited on 11 Feb 2008
21 downloads since 12 months
|Item Type:||Journal Article, refereed|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|Dewey Decimal Classification:||570 Life sciences; biology|
|Date:||29 November 1996|
|Deposited On:||11 Feb 2008 12:19|
|Last Modified:||27 Nov 2013 19:38|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page