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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-996

Zecca, M; Basler, K; Struhl, G (1996). Direct and long-range action of a wingless morphogen gradient. Cell, 87(5):833-844.

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Wingless (Wg), a founding member of the Wingless/Int-1 (Wnt) family of secreted proteins, acts as a short-range inducer and as a long-range organizer during Drosophila development. Here, we determine the consequences of ectopically expressing (i) a wild-type form of Wg, (ii) a membrane-tethered form of Wg, and (iii) a constitutively active form of the cytosolic protein Armadillo (Arm), which normally acts to transduce Wg, and we compare them with the effects of removing endogenous Wg or Arm activity. Our results indicate that wild-type Wg acts at long range, up-regulating the transcription of particular target genes as a function of concentration and distance from secreting cells. In contrast, tethered Wg and Arm have only short-range or autonomous effects, respectively, on the transcription of these genes. We interpret these findings as evidence that Wg can act directly and at long range as a gradient morphogen during normal development.


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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Date:29 November 1996
Deposited On:11 Feb 2008 12:19
Last Modified:27 Nov 2013 19:38
Publisher DOI:10.1016/S0092-8674(00)81991-1
PubMed ID:8945511

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