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Antibody responses following induction of antigen-specific tolerance with antigen-coupled cells


Peschl, Patrick; Reindl, Markus; Schanda, Kathrin; Sospedra, Mireia; Martin, Roland; Lutterotti, Andreas (2015). Antibody responses following induction of antigen-specific tolerance with antigen-coupled cells. Multiple Sclerosis, 21(5):651-655.

Abstract

We have recently demonstrated the safety and tolerability of a novel therapeutic regimen employing autologous blood cells chemically coupled with seven myelin peptides to induce antigen-specific tolerance in MS (ETIMS study). The aim of the current study was an extended safety analysis to assess the effect of the ETIMS approach on antibodies to common autoantigens, the myelin peptides used and common recall antigens. None of the patients showed induction of autoantibody responses. One patient had a measurable myelin peptide-specific response at baseline, which was reduced after treatment. Total immunoglobulins and recall antibody responses showed no significant change.

We have recently demonstrated the safety and tolerability of a novel therapeutic regimen employing autologous blood cells chemically coupled with seven myelin peptides to induce antigen-specific tolerance in MS (ETIMS study). The aim of the current study was an extended safety analysis to assess the effect of the ETIMS approach on antibodies to common autoantigens, the myelin peptides used and common recall antigens. None of the patients showed induction of autoantibody responses. One patient had a measurable myelin peptide-specific response at baseline, which was reduced after treatment. Total immunoglobulins and recall antibody responses showed no significant change.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2015
Deposited On:23 Oct 2014 11:22
Last Modified:05 Apr 2016 18:25
Publisher:Sage Publications Ltd.
ISSN:1352-4585
Publisher DOI:https://doi.org/10.1177/1352458514549405
PubMed ID:25200502
Permanent URL: https://doi.org/10.5167/uzh-99617

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