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Revolutioniert Kollagenase die Chirurgie?


Frueh, Florian Samuel; Calcagni, Maurizio (2014). Revolutioniert Kollagenase die Chirurgie? Therapeutische Umschau. Revue thérapeutique, 71(7):379-384.

Abstract

Up to date, Dupuytren's contracture is a disease without cure. Almost 20 years ago, enzymatic cord degradation with clostridial collagenase was described for the first time. Whereas until recently limited fasciectomy was the treatment of choice for most of the patients, now collagenase offers a minimally invasive treatment in cases with palpable cords. Collagenase is a safe and effective treatment with success rates around 85 % for MCP joint and 65 % for PIP joints and a low complication rate. One point of concern is the recurrence rate which is higher compared to open surgery. A review of the literature is presented, technique and indication for collagenase are discussed.

Abstract

Up to date, Dupuytren's contracture is a disease without cure. Almost 20 years ago, enzymatic cord degradation with clostridial collagenase was described for the first time. Whereas until recently limited fasciectomy was the treatment of choice for most of the patients, now collagenase offers a minimally invasive treatment in cases with palpable cords. Collagenase is a safe and effective treatment with success rates around 85 % for MCP joint and 65 % for PIP joints and a low complication rate. One point of concern is the recurrence rate which is higher compared to open surgery. A review of the literature is presented, technique and indication for collagenase are discussed.

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Additional indexing

Other titles:Collagenase-A revolution of Dupuytren's therapy
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Reconstructive Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:July 2014
Deposited On:04 Nov 2014 08:21
Last Modified:08 Dec 2017 07:48
Publisher:Hogrefe Verlag
ISSN:0040-5930
Publisher DOI:https://doi.org/10.1024/0040-5930/a000526
PubMed ID:24972516

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