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Thiourea-Based fluorescent chemosensors for aqueous metal ion detection and cellular imaging


Vonlanthen, Mireille; Connelly, Colleen M; Deiters, Alexander; Linden, Anthony; Finney, Nathaniel S (2014). Thiourea-Based fluorescent chemosensors for aqueous metal ion detection and cellular imaging. Journal of Organic Chemistry, 79(13):6054-6060.

Abstract

We describe three significant advances in the use of thioureas as reporting elements for metal-responsive fluorescent chemosensors. First, on the basis of the crystal structure of a chemosensor analogue, we provide a deeper understanding of the details of the thiourea coordination environment. Second, we describe a new generation of chemosensors with higher affinities for Zn2+ and Cd2+ than were observed for earlier probes, expanding the scope of this type of probe beyond Hg2+ detection. Third, we show that a thiourea-based chemosensor can be employed for fluorescence microscopy imaging of Hg2+ ion concentrations in living mammalian cells.

Abstract

We describe three significant advances in the use of thioureas as reporting elements for metal-responsive fluorescent chemosensors. First, on the basis of the crystal structure of a chemosensor analogue, we provide a deeper understanding of the details of the thiourea coordination environment. Second, we describe a new generation of chemosensors with higher affinities for Zn2+ and Cd2+ than were observed for earlier probes, expanding the scope of this type of probe beyond Hg2+ detection. Third, we show that a thiourea-based chemosensor can be employed for fluorescence microscopy imaging of Hg2+ ion concentrations in living mammalian cells.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2014
Deposited On:06 Nov 2014 14:31
Last Modified:05 Apr 2016 18:28
Publisher:American Chemical Society
ISSN:0022-3263
Funders:Swiss National Science Foundation, UZH Institute of Organic Chemistry, GlaxoSmithKline graduate fellowship
Publisher DOI:https://doi.org/10.1021/jo500710g
PubMed ID:24957917

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