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The investigation of acute optic neuritis: a review and proposed protocol


Petzold, A; Wattjes, M P; Costello, F; Flores-Rivera, J; Fraser, C L; Fujihara, K; Leavitt, J; Marignier, R; Paul, F; Schippling, S; Sindic, C; Villoslada, P; Weinshenker, B; Plant, G T (2014). The investigation of acute optic neuritis: a review and proposed protocol. Nature Reviews. Neurology, 10(8):447-58.

Abstract

Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To date, however, no consensus guidelines have been devised to specify how and when these techniques can be most rationally applied for the diagnostic work-up of patients with acute optic neuritis. In this article, we review the literature and attempt to formulate a consensus for the investigation of patients with acute optic neuritis, both in standard care and in research with relevance to clinical treatment trials.

Abstract

Optic neuritis is an inflammatory optic neuropathy that affects many patients with multiple sclerosis (MS) at some point during their disease course. Differentiation of acute episodes of MS-associated optic neuritis from other autoimmune and inflammatory optic neuropathies is vital for treatment choice and further patient management, but is not always straightforward. Over the past decade, a number of new imaging, laboratory and electrophysiological techniques have entered the clinical arena. To date, however, no consensus guidelines have been devised to specify how and when these techniques can be most rationally applied for the diagnostic work-up of patients with acute optic neuritis. In this article, we review the literature and attempt to formulate a consensus for the investigation of patients with acute optic neuritis, both in standard care and in research with relevance to clinical treatment trials.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:August 2014
Deposited On:26 Jan 2015 08:27
Last Modified:05 Apr 2016 18:29
Publisher:Nature Publishing Group
ISSN:1759-4758
Publisher DOI:https://doi.org/10.1038/nrneurol.2014.108
PubMed ID:25002105

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