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Inheritance of etopic ureters in Entlebucher Mountain Dogs


Fritsche, R; Dolf, G; Schelling, C; Hungerbühler, S O; Hagen, R; Reichler, I M (2014). Inheritance of etopic ureters in Entlebucher Mountain Dogs. Journal of Animal Breeding and Genetics = Zeitschrift für Tierzüchtung und Züchtungsbiologie, 131(2):146-152.

Abstract

To test the hypothesis of a heritable base of ectopic ureters (EU) in Entlebucher Mountain Dogs (EMD) and to elucidate associated risk factors and mode of inheritance of the disease, 565 EMD were clinically investigated and population genetic analyses performed. Based on the location of the most caudal termination of the ureteral openings, 552 EMD were classified into three phenotype groups trigone, intravesically and extravesically ectopic based on results of abdominal sonography, urethra-cystoscopy and/or contrast-enhanced computed tomography. One-third (32.9%) of the phenotyped animals had normal terminations of both ureters in the bladder trigone, 47.3% had at least one intravesicular ectopic termination and 19.8% had at least one extravesicular ectopic termination. Multivariate mixed logistic regression revealed gender as a risk factor associated with EU as males were more often affected than females. Complex segregation analysis indicated a hereditary basis for EU in EMD and the involvement of a major gene in the occurrence of the extravesicular EU phenotype.

Abstract

To test the hypothesis of a heritable base of ectopic ureters (EU) in Entlebucher Mountain Dogs (EMD) and to elucidate associated risk factors and mode of inheritance of the disease, 565 EMD were clinically investigated and population genetic analyses performed. Based on the location of the most caudal termination of the ureteral openings, 552 EMD were classified into three phenotype groups trigone, intravesically and extravesically ectopic based on results of abdominal sonography, urethra-cystoscopy and/or contrast-enhanced computed tomography. One-third (32.9%) of the phenotyped animals had normal terminations of both ureters in the bladder trigone, 47.3% had at least one intravesicular ectopic termination and 19.8% had at least one extravesicular ectopic termination. Multivariate mixed logistic regression revealed gender as a risk factor associated with EU as males were more often affected than females. Complex segregation analysis indicated a hereditary basis for EU in EMD and the involvement of a major gene in the occurrence of the extravesicular EU phenotype.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Language:English
Date:2014
Deposited On:30 Dec 2014 16:20
Last Modified:27 Apr 2017 21:52
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0931-2668
Additional Information:This is the accepted version of the following article: [Fritsche, R., Dolf, G., Schelling, C., Hungerbuehler, S. O., Hagen, R. and Reichler, I. M. (2014), Inheritance of ectopic ureters in Entlebucher Mountain Dogs. Journal of Animal Breeding and Genetics, 131: 146–152. doi: 10.1111/jbg.12055], which has been published in final form at [http://onlinelibrary.wiley.com/doi/10.1111/jbg.12055/abstract]
Publisher DOI:https://doi.org/10.1111/jbg.12055
PubMed ID:24628724

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