Header

UZH-Logo

Maintenance Infos

Lymphoepithelial carcinoma of the salivary glands: case report of a rare cancer and review of the literature


Holz-Sapra, E; Glanzmann, C; Schmid, S; Went, P; Studer, G (2014). Lymphoepithelial carcinoma of the salivary glands: case report of a rare cancer and review of the literature. Journal of Medical Research and Development, 3(4):184-192.

Abstract

Objective: Lymphoepithelial carcinoma (LEC) of the salivary glands is a very rare condition especially in the Caucasian population. We herewith contribute a case of a Caucasian woman with LEC of the parotid gland. Furthermore we present a literature review on LEC of the major salivary glands (MSG) of the past 32 years. Materials and Methods: We reported an own case and performed a review of the medical literature (1980-2012). Results: Case report: After a Follow-up (FU) of 5 years after treatment with postoperative IMRT and concomitant carboplatin, our patient has no signs of relapse. Review: We found 404 cases with LEC of the MSG published in 33 articles over the last 32 years. The mean age of the patients was 49 years (16-86); 56% were female. 95% of the cases have been treated and published in Asia (China, Taiwan). Only 17 of the 404 cases (4%) reported in 15 publications, Caucasian patients were affected. Information on treatment and outcome was not available in 75% and 72%, respectively. After a mean FU of 5.5 years (range 0.5-14) 66 of 84 (79%) patients with reported FU showed no evidence of disease. Conclusion: LEC of the salivary glands is a rare disease especially in Caucasian populations with only 4% of published LEC cases in the reviewed literature. In only 21% of the reports, clinical information on treatment and outcome was provided. Based on the limited information available from published reports, the value of radiotherapy remains unclear.

Abstract

Objective: Lymphoepithelial carcinoma (LEC) of the salivary glands is a very rare condition especially in the Caucasian population. We herewith contribute a case of a Caucasian woman with LEC of the parotid gland. Furthermore we present a literature review on LEC of the major salivary glands (MSG) of the past 32 years. Materials and Methods: We reported an own case and performed a review of the medical literature (1980-2012). Results: Case report: After a Follow-up (FU) of 5 years after treatment with postoperative IMRT and concomitant carboplatin, our patient has no signs of relapse. Review: We found 404 cases with LEC of the MSG published in 33 articles over the last 32 years. The mean age of the patients was 49 years (16-86); 56% were female. 95% of the cases have been treated and published in Asia (China, Taiwan). Only 17 of the 404 cases (4%) reported in 15 publications, Caucasian patients were affected. Information on treatment and outcome was not available in 75% and 72%, respectively. After a mean FU of 5.5 years (range 0.5-14) 66 of 84 (79%) patients with reported FU showed no evidence of disease. Conclusion: LEC of the salivary glands is a rare disease especially in Caucasian populations with only 4% of published LEC cases in the reviewed literature. In only 21% of the reports, clinical information on treatment and outcome was provided. Based on the limited information available from published reports, the value of radiotherapy remains unclear.

Statistics

Downloads

42 downloads since deposited on 24 Mar 2015
38 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Radiation Oncology
Dewey Decimal Classification:610 Medicine & health
Date:2014
Deposited On:24 Mar 2015 13:00
Last Modified:27 Apr 2017 21:56
Publisher:World Academic Publishing Inc.
ISSN:2303-9345
Official URL:http://www.academicpub.org/jmrd/paperInfo.aspx?PaperID=15682
Related URLs:http://www.academicpub.org/jmrd/ (Publisher)

Download

Preview Icon on Download
Preview
Content: Published Version
Filetype: PDF
Size: 1MB

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations