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Prevalence and predictors for homo- and heterosubtypic antibodies against influenza a virus


Kohler, Ines; Scherrer, A U; Zagordi, O; Bianchi, M; Wyrzucki, A; Steck, M; Ledergerber, B; Gunthard, H F; Hangartner, L (2014). Prevalence and predictors for homo- and heterosubtypic antibodies against influenza a virus. Clinical Infectious Diseases, 59(10):1386-1393.

Abstract

Background: The effectiveness of trivalent influenza vaccination has been confirmed in several studies. To date, it is not known whether repeated exposure and vaccination to influenza promote production of cross-reactive anti-bodies. Furthermore, how strains encountered earlier in life imprint the immune response is currently poorly understood.
Methods: To determine the prevalence for human homo- and heterosubtypic antibody responses, we scruti-nized serum samples from 305 healthy volunteers for hemagglutinin-binding and -neutralizing antibodies against several strains and subtypes of influenza A. Statistical analyses were then performed to establish the association of
measured values with potential predictors.
Results: It was found that vaccination not only promoted higher binding and neutralizing antibody titers to homosubtypic in
fluenza isolates but also increased heterosubtypic human immune responses. Both binding and neutralizing antibody titers in relation with age of the donors mirrored the course of the different influenza strain circulation during the last century. Advanced age appeared to be of advantage for both binding and neutralizing titers to most subtypes. In contrast, the first virus subtype encountered was found to imprint to some degree subsequent antibody responses. Antibodies to recent strains, however, primarily seemed to be promoted by vaccination.
Conclusions: We provide evidence that vaccinations stimulate both homo- and heterosubtypic immune responses in young and middle-aged as well as more senior individuals. Our analyses suggest that influenza vaccinations not only prevent infection against currently circulating strains but can also stimulate broader humoral immune responses that potentially attenuate infections with zoonotic or antigenically shifted strains.

Abstract

Background: The effectiveness of trivalent influenza vaccination has been confirmed in several studies. To date, it is not known whether repeated exposure and vaccination to influenza promote production of cross-reactive anti-bodies. Furthermore, how strains encountered earlier in life imprint the immune response is currently poorly understood.
Methods: To determine the prevalence for human homo- and heterosubtypic antibody responses, we scruti-nized serum samples from 305 healthy volunteers for hemagglutinin-binding and -neutralizing antibodies against several strains and subtypes of influenza A. Statistical analyses were then performed to establish the association of
measured values with potential predictors.
Results: It was found that vaccination not only promoted higher binding and neutralizing antibody titers to homosubtypic in
fluenza isolates but also increased heterosubtypic human immune responses. Both binding and neutralizing antibody titers in relation with age of the donors mirrored the course of the different influenza strain circulation during the last century. Advanced age appeared to be of advantage for both binding and neutralizing titers to most subtypes. In contrast, the first virus subtype encountered was found to imprint to some degree subsequent antibody responses. Antibodies to recent strains, however, primarily seemed to be promoted by vaccination.
Conclusions: We provide evidence that vaccinations stimulate both homo- and heterosubtypic immune responses in young and middle-aged as well as more senior individuals. Our analyses suggest that influenza vaccinations not only prevent infection against currently circulating strains but can also stimulate broader humoral immune responses that potentially attenuate infections with zoonotic or antigenically shifted strains.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Virology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Uncontrolled Keywords:influenza virus; heterosubtypic antibodies; prevalence; predictors
Language:English
Date:12 August 2014
Deposited On:27 Nov 2014 11:59
Last Modified:18 Apr 2018 11:45
Publisher:Oxford University Press
ISSN:1058-4838
Funders:Swiss National Science Foundation (grant numbers PP00P3_123429, PP00P3_146345 to L. H. and 130865 to H. F. G.).
Additional Information:This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Clinical Infectious Diseases following peer review. The definitive publisher-authenticated version is available online at: DOI: 10.1093/cid/ciu660
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/cid/ciu660
Related URLs:http://cid.oxfordjournals.org/content/59/10/1386.full.pdf+html?sid=ca562c4e-9391-4cbe-b810-caade4bbf191 (Publisher)
http://cid.oxfordjournals.org (Publisher)
PubMed ID:25139962
Project Information:
  • : FunderSNSF
  • : Grant ID
  • : Project TitleSwiss National Science Foundation (grant numbers PP00P3_123429, PP00P3_146345 to L. H. and 130865 to H. F. G.).

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