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Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice


Gapp, Katharina; Jawaid, Ali; Sarkies, Peter; Bohacek, Johannes; Pelczar, Pawel; Prados, Julien; Farinelli, Laurent; Miska, Eric; Mansuy, Isabelle M (2014). Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice. Nature Neuroscience, 17(5):667-669.

Abstract

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

Abstract

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) expression, and behavioral and metabolic responses in the progeny. Injection of sperm RNAs from traumatized males into fertilized wild-type oocytes reproduced the behavioral and metabolic alterations in the resulting offspring.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:05 Vetsuisse Faculty > Institute of Laboratory Animal Science
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:May 2014
Deposited On:05 Dec 2014 13:34
Last Modified:02 Oct 2016 06:58
Publisher:Nature Publishing Group
ISSN:1097-6256
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1038/nn.3695
PubMed ID:24728267

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