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Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans.


Hengartner, M O (1997). Genetic control of programmed cell death and aging in the nematode Caenorhabditis elegans. Experimental Gerontology, 32(4-5):363-374.

Abstract

The nematode Caenorhabditis elegans has been used extensively as a model system for the study of basic biological processes. In this species, apoptosis and aging are both under genetic control. Molecular studies have shown that the death machinery that kills C. elegans cells has remained conserved through evolution and also functions to promote apoptotic death in mammalian cells. At least some of the genes that affect C. elegans life span are also evolutionarily conserved; whether the vertebrate homologs of these genes also influence life span remains to be determined. Although a large number of mutations have been isolated that affect either apoptosis or aging in C. elegans, there is so far no evidence that the genetic pathways that control these processes might overlap.

Abstract

The nematode Caenorhabditis elegans has been used extensively as a model system for the study of basic biological processes. In this species, apoptosis and aging are both under genetic control. Molecular studies have shown that the death machinery that kills C. elegans cells has remained conserved through evolution and also functions to promote apoptotic death in mammalian cells. At least some of the genes that affect C. elegans life span are also evolutionarily conserved; whether the vertebrate homologs of these genes also influence life span remains to be determined. Although a large number of mutations have been isolated that affect either apoptosis or aging in C. elegans, there is so far no evidence that the genetic pathways that control these processes might overlap.

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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:July 1997
Deposited On:11 Feb 2008 12:20
Last Modified:20 Feb 2018 08:31
Publisher:Elsevier
ISSN:0531-5565
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/S0531-5565(96)00167-2
PubMed ID:9315441

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