Header

UZH-Logo

Maintenance Infos

Shared microbiome in gums and the lung in an outpatient population


Schmidlin, Patrick R; Fachinger, Patrick; Tini, Gabrielo; Graber, Sereina; Seifert, Burkhardt; Dombrowa, Sylke; Irani, Sarosh (2015). Shared microbiome in gums and the lung in an outpatient population. Journal of Infection, 70(3):255-263.

Abstract

OBJECTIVES: Whether periopathogenic bacteria occur in the lung and gums simultaneously and what impact periodontitis has is unknown.
METHODS: In consecutive outpatients scheduled for bronchoscopies we performed a periodontal screening index. PCR to determine four periopathogens and seven less pathogenic species in both the periodontal pocket and bronchial protected specimen brush was used. Activated MMP8 in saliva and bronchial fluid was measured.
RESULTS: Periopathogens were detectable in gums and in the bronchial protected specimen brush in 75 (80%) and 27 (30%) of the cases, respectively. The concentration of activated MMP 8 was above 40 ng/ml in the saliva and in the bronchial fluid sample in six and 31 subjects, respectively. Significant agreement between the periodontal and bronchial compartment was found in three out of the four periopathogens. Patients with periopathogens in the lung suffered from periodontitis more frequently (p = 0.01). In patients with periopathogens detectable in the lung the concentration of aMMP8 tends to be more frequently above 40 ng/ml in the bronchial fluid (p = 0.09).
CONCLUSIONS: Agreement between periodontal and bronchial microbiome is more distinct for periopathogens than for less pathogenic species. Periodontitis itself represents a risk factor for pulmonary colonization with certain periopathogens. Pulmonary colonization with periopathogens seems to be associated with increased local inflammation.

Abstract

OBJECTIVES: Whether periopathogenic bacteria occur in the lung and gums simultaneously and what impact periodontitis has is unknown.
METHODS: In consecutive outpatients scheduled for bronchoscopies we performed a periodontal screening index. PCR to determine four periopathogens and seven less pathogenic species in both the periodontal pocket and bronchial protected specimen brush was used. Activated MMP8 in saliva and bronchial fluid was measured.
RESULTS: Periopathogens were detectable in gums and in the bronchial protected specimen brush in 75 (80%) and 27 (30%) of the cases, respectively. The concentration of activated MMP 8 was above 40 ng/ml in the saliva and in the bronchial fluid sample in six and 31 subjects, respectively. Significant agreement between the periodontal and bronchial compartment was found in three out of the four periopathogens. Patients with periopathogens in the lung suffered from periodontitis more frequently (p = 0.01). In patients with periopathogens detectable in the lung the concentration of aMMP8 tends to be more frequently above 40 ng/ml in the bronchial fluid (p = 0.09).
CONCLUSIONS: Agreement between periodontal and bronchial microbiome is more distinct for periopathogens than for less pathogenic species. Periodontitis itself represents a risk factor for pulmonary colonization with certain periopathogens. Pulmonary colonization with periopathogens seems to be associated with increased local inflammation.

Statistics

Citations

5 citations in Web of Science®
5 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Microbiome; Periodontitis; Bronchial inflammation; Periopathogens
Language:English
Date:2015
Deposited On:29 Dec 2014 11:55
Last Modified:05 Apr 2016 18:42
Publisher:Elsevier
ISSN:0163-4453
Publisher DOI:https://doi.org/10.1016/j.jinf.2014.10.005
PubMed ID:25445885

Download

Full text not available from this repository.
View at publisher