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Pulmonary hypertension: Classification and pathobiology


Huber, Lars C; Vrugt, Bart; Arrigo, Mattia (2014). Pulmonary hypertension: Classification and pathobiology. Cardiovascular Medicine, 17(11):312-319.

Abstract

Pulmonary hypertension is defined as an increase of the mean pulmonary arterial pressure above 25 mm Hg and, as such, the diagnosis requires invasive haemodynamic measurement by right heart catheterisation. More than just a single disease, pulmonary hypertension is an umbrella term that includes many different disorders and pathophysiological entities. However, most forms of pulmonary hypertension share a final common pathway, in particular the trias of vasoconstriction, microthrombosis and vascular remodelling. The classification of pulmonary hypertension has been subjected to many changes within the last decade. At the same time, major achievements in our understanding of the complex pathobiology have been made. Here, these developments are discussed in the light of the recently published report from the fifth World Symposium on pulmonary hypertension.

Abstract

Pulmonary hypertension is defined as an increase of the mean pulmonary arterial pressure above 25 mm Hg and, as such, the diagnosis requires invasive haemodynamic measurement by right heart catheterisation. More than just a single disease, pulmonary hypertension is an umbrella term that includes many different disorders and pathophysiological entities. However, most forms of pulmonary hypertension share a final common pathway, in particular the trias of vasoconstriction, microthrombosis and vascular remodelling. The classification of pulmonary hypertension has been subjected to many changes within the last decade. At the same time, major achievements in our understanding of the complex pathobiology have been made. Here, these developments are discussed in the light of the recently published report from the fifth World Symposium on pulmonary hypertension.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Pneumology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:November 2014
Deposited On:13 Jan 2015 09:48
Last Modified:05 Apr 2016 18:42
Publisher:EMH Swiss Medical Publishers
ISSN:1423-5528
Free access at:Official URL. An embargo period may apply.
Official URL:http://www.cardiovascmed.ch/docs/cvm/2014/11/en/cvm_00286.pdf
Related URLs:http://www.cardiovascmed.ch

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