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Phenotypical and therapeutic studies in genetic mouse models for inherited neurotransmitter disorders


Korner, Germaine Florence. Phenotypical and therapeutic studies in genetic mouse models for inherited neurotransmitter disorders. 2014, University of Zurich, Faculty of Science.

Abstract

The present dissertation is based on characterization of mouse models for inborn errors of metabolic disorders concomitant with monoamine neurotransmitter deficiency and investigation of potential therapeutic approaches. Following an introduction (Chapter 1), this dissertation deals with the three metabolic diseases tyrosine hydroxylase deficiency (THD; chapter 2), tetrahydrobiopterin deficiency (BH4 deficiency; chapter 3), and classical phenylketonuria (cPKU; chapter 4). Chapter 2: Tyrosine hydroxylase knock-in (Th-ki) mouse model with catecholamine depletion and impaired motor control: Characterisation and treatment studies.

Abstract

The present dissertation is based on characterization of mouse models for inborn errors of metabolic disorders concomitant with monoamine neurotransmitter deficiency and investigation of potential therapeutic approaches. Following an introduction (Chapter 1), this dissertation deals with the three metabolic diseases tyrosine hydroxylase deficiency (THD; chapter 2), tetrahydrobiopterin deficiency (BH4 deficiency; chapter 3), and classical phenylketonuria (cPKU; chapter 4). Chapter 2: Tyrosine hydroxylase knock-in (Th-ki) mouse model with catecholamine depletion and impaired motor control: Characterisation and treatment studies.

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Additional indexing

Item Type:Dissertation
Referees:Thöny Beat, Verrey François, Mansuy Isabelle M
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2014
Deposited On:30 Dec 2014 15:59
Last Modified:26 Jan 2017 08:57

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