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Morphologic and molecular backgrounds for personalized management of genito-urinary cancers: an Overview


Montironi, Rodolfo; Santoni, Matteo; Lopez-Beltran, Antonio; Cheng, Liang; Moch, Holger; Scarpelli, Marina (2014). Morphologic and molecular backgrounds for personalized management of genito-urinary cancers: an Overview. Current Drug Targets, 16(2):96-102.

Abstract

This contribution gives an overview of recent insights and emerging strategies for individualized therapeutic approaches based on patient's genomic and cancer's molecular profiles in patients with a morphological diagnosis of renal, bladder and prostate tumors. Significant advances have been made in molecular biology technologies, such as next-generation sequencing and whole-exome sequencing. The rise of such novel techniques has increased our knowledge on tumor cell biology and cancer development, thus allowing to identify complex genomic abnormalities. These findings have paved the way to provide healthcare from an individual perspective. An emerging strategy to individualize therapeutic interventions is focused on stem cells. Because of their unique characteristics, they are among the most promising candidates as potential vectors carrying suicide genes into different types of cancer, including genitourinary tumors. Another emerging strategy could be based on prostate specific membrane antigen (PSMA), a unique membrane bound glycoprotein, which is overexpressed manifold on prostate cancer. PSMA can serve as target for delivery of therapeutic agents such as cytotoxins or radionuclides.

Abstract

This contribution gives an overview of recent insights and emerging strategies for individualized therapeutic approaches based on patient's genomic and cancer's molecular profiles in patients with a morphological diagnosis of renal, bladder and prostate tumors. Significant advances have been made in molecular biology technologies, such as next-generation sequencing and whole-exome sequencing. The rise of such novel techniques has increased our knowledge on tumor cell biology and cancer development, thus allowing to identify complex genomic abnormalities. These findings have paved the way to provide healthcare from an individual perspective. An emerging strategy to individualize therapeutic interventions is focused on stem cells. Because of their unique characteristics, they are among the most promising candidates as potential vectors carrying suicide genes into different types of cancer, including genitourinary tumors. Another emerging strategy could be based on prostate specific membrane antigen (PSMA), a unique membrane bound glycoprotein, which is overexpressed manifold on prostate cancer. PSMA can serve as target for delivery of therapeutic agents such as cytotoxins or radionuclides.

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6 citations in Web of Science®
5 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 December 2014
Deposited On:13 Jan 2015 16:44
Last Modified:08 Dec 2017 09:42
Publisher:Bentham Science Publishers
ISSN:1389-4501
Publisher DOI:https://doi.org/10.2174/1389450115666141202113805
Official URL:http://benthamscience.com/journal/abstracts.php?journalID=cdt&articleID=126561
PubMed ID:25469883

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