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Model-based iterative reconstruction for improvement of low-contrast detectability in liver CT at reduced radiation dose: Ex-vivo experience


Husarik, D B; Alkadhi, H; Puippe, G D; Reiner, C S; Chuck, N C; Morsbach, F; Szucs-Farkas, Z; Schindera, S T (2015). Model-based iterative reconstruction for improvement of low-contrast detectability in liver CT at reduced radiation dose: Ex-vivo experience. Clinical Radiology, 70(4):366-372.

Abstract

AIM: To compare low-contrast detectability, and qualitative and quantitative image parameters on standard and reduced radiation dose abdominal CT reconstructed with filtered back projection (FBP) and model-based iterative reconstruction (MBIR).
MATERIALS AND METHODS: A custom built liver phantom containing 43 lesions was imaged at 120 kVp and four radiation dose levels (100% = 188 mAs, 50%, 25%, and 10%). Image noise and contrast-to-noise ratios (CNR) were assessed. Lesion detection and qualitative image analysis (five-point Likert scale with 1 = worst, 5 = best for confidence) was performed by three independent radiologists.
RESULTS: CNR on MBIR images was significantly higher (mean 246%, range 151-383%) and image noise was significantly lower (69%, 59-78%) than on FBP images at the same radiation dose (both p < 0.05). On MBIR 10% images, CNR (3.3 ± 0.3) was significantly higher and noise (15 ± 1HU) significantly lower than on FBP 100% images (2.5 ± 0.1; 21 ± 1 HU). On 100% images, lesion attenuation was significantly lower with MBIR than with FBP (mean difference -2 HU). Low-contrast detectability and qualitative results were similar with MBIR 50% and FBP 100%.
CONCLUSION: Low-contrast detectability with MBIR 50% and FBP 100% were equal. Quantitative parameters on even lower dose MBIR images are superior to 100%-dose FBP images. Some attenuation values differ significantly with MBIR compared with FBP.

Abstract

AIM: To compare low-contrast detectability, and qualitative and quantitative image parameters on standard and reduced radiation dose abdominal CT reconstructed with filtered back projection (FBP) and model-based iterative reconstruction (MBIR).
MATERIALS AND METHODS: A custom built liver phantom containing 43 lesions was imaged at 120 kVp and four radiation dose levels (100% = 188 mAs, 50%, 25%, and 10%). Image noise and contrast-to-noise ratios (CNR) were assessed. Lesion detection and qualitative image analysis (five-point Likert scale with 1 = worst, 5 = best for confidence) was performed by three independent radiologists.
RESULTS: CNR on MBIR images was significantly higher (mean 246%, range 151-383%) and image noise was significantly lower (69%, 59-78%) than on FBP images at the same radiation dose (both p < 0.05). On MBIR 10% images, CNR (3.3 ± 0.3) was significantly higher and noise (15 ± 1HU) significantly lower than on FBP 100% images (2.5 ± 0.1; 21 ± 1 HU). On 100% images, lesion attenuation was significantly lower with MBIR than with FBP (mean difference -2 HU). Low-contrast detectability and qualitative results were similar with MBIR 50% and FBP 100%.
CONCLUSION: Low-contrast detectability with MBIR 50% and FBP 100% were equal. Quantitative parameters on even lower dose MBIR images are superior to 100%-dose FBP images. Some attenuation values differ significantly with MBIR compared with FBP.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2015
Deposited On:15 Jan 2015 11:37
Last Modified:14 Feb 2018 08:47
Publisher:Elsevier
ISSN:0009-9260
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.crad.2014.11.015
PubMed ID:25554541

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