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Long-term efficacy of postpartum intravenous iron therapy


Becuzzi, Nadine; Zimmermann, Roland; Krafft, Alexander (2014). Long-term efficacy of postpartum intravenous iron therapy. BioMed Research International, 2014:815437.

Abstract

BACKGROUND: The potential benefits of administering a dose of intravenous iron in patients with moderate postpartum anaemia rather than oral iron alone remains unproven.
AIMS: To determine whether a single injection of intravenous iron followed by a 6-week course of oral iron is as effective over 6 months in restoring normal haemoglobin levels and replenishing iron stores in women with moderate postpartum anaemia as a course of oral iron alone in women with mild postpartum anaemia.
MATERIALS AND METHODS: Retrospective two-arm cohort study in women with mild postpartum anaemia (haemoglobin 9.6-10.5 g/dL) prescribed iron daily for 6 weeks (N=150) and women with moderate postpartum anaemia (haemoglobin 8.5-9.5 g/dL), given a single 500 mg injection of intravenous iron followed by iron daily for 6 weeks (N=75). Haemoglobin and ferritin were measured 6 months postpartum.
RESULTS: Haemoglobin returned to similar mean levels in both groups. Ferritin levels were statistically significantly higher in the intravenous+oral group (57.7±49.3 μg/L versus 32.9±20.1 μg/L).
CONCLUSIONS: Despite lower baseline haemoglobin, intravenous iron carboxymaltose was superior to oral iron alone in replenishing iron stores in moderate postpartum anaemia and may prove similarly beneficial in mild postpartum anaemia.

Abstract

BACKGROUND: The potential benefits of administering a dose of intravenous iron in patients with moderate postpartum anaemia rather than oral iron alone remains unproven.
AIMS: To determine whether a single injection of intravenous iron followed by a 6-week course of oral iron is as effective over 6 months in restoring normal haemoglobin levels and replenishing iron stores in women with moderate postpartum anaemia as a course of oral iron alone in women with mild postpartum anaemia.
MATERIALS AND METHODS: Retrospective two-arm cohort study in women with mild postpartum anaemia (haemoglobin 9.6-10.5 g/dL) prescribed iron daily for 6 weeks (N=150) and women with moderate postpartum anaemia (haemoglobin 8.5-9.5 g/dL), given a single 500 mg injection of intravenous iron followed by iron daily for 6 weeks (N=75). Haemoglobin and ferritin were measured 6 months postpartum.
RESULTS: Haemoglobin returned to similar mean levels in both groups. Ferritin levels were statistically significantly higher in the intravenous+oral group (57.7±49.3 μg/L versus 32.9±20.1 μg/L).
CONCLUSIONS: Despite lower baseline haemoglobin, intravenous iron carboxymaltose was superior to oral iron alone in replenishing iron stores in moderate postpartum anaemia and may prove similarly beneficial in mild postpartum anaemia.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Obstetrics
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2014
Deposited On:13 Jan 2015 15:07
Last Modified:04 Aug 2017 11:22
Publisher:Hindawi Publishing Corporation
ISSN:2314-6133
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1155/2014/815437
PubMed ID:25431768

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