Header

UZH-Logo

Maintenance Infos

Detection of Helicobacter pylori in head and neck cancer patients: Results from a prospective comparative study combining serology, PCR, and rapid urease test


Morand, Grégoire B; Fellmann, Jonas; Laske, Roman D; Weisert, Jan U; Soltermann, Alex; Zbinden, Reinhard; Probst, Rudolf; Huber, Gerhard F (2016). Detection of Helicobacter pylori in head and neck cancer patients: Results from a prospective comparative study combining serology, PCR, and rapid urease test. Head and Neck, 38(5):769-774.

Abstract

BACKGROUND: The goal of this study was to evaluate prospectively the presence and impact of the gastric carcinogen Helicobacter pylori in the upper aerodigestive tract. Previous studies suggested it could represent a risk factor for head and neck squamous cell carcinoma.
METHODS: Serology, rapid urease test, and quantitative polymerase chain reaction (qPCR) for H. pylori were performed in head and neck cancer patients (N=56) and cancer-free controls (N=90). Comparison between groups was done using logistic regression analysis.
RESULTS: Rates of positive serology and rapid urease test did not differ between the two groups in logistic regression analysis (P=0.677 and P=0.633, respectively). Birth in a developing country and age above 50 years old were predictors of positive serology (P<0.001 and P=0.040, respectively). Using qPCR, no biopsy showed presence of H.pylori.
CONCLUSION: This study challenges the concept that H. pylori may be a risk factor for head and neck squamous cell carcinoma. This article is protected by copyright. All rights reserved.

Abstract

BACKGROUND: The goal of this study was to evaluate prospectively the presence and impact of the gastric carcinogen Helicobacter pylori in the upper aerodigestive tract. Previous studies suggested it could represent a risk factor for head and neck squamous cell carcinoma.
METHODS: Serology, rapid urease test, and quantitative polymerase chain reaction (qPCR) for H. pylori were performed in head and neck cancer patients (N=56) and cancer-free controls (N=90). Comparison between groups was done using logistic regression analysis.
RESULTS: Rates of positive serology and rapid urease test did not differ between the two groups in logistic regression analysis (P=0.677 and P=0.633, respectively). Birth in a developing country and age above 50 years old were predictors of positive serology (P<0.001 and P=0.040, respectively). Using qPCR, no biopsy showed presence of H.pylori.
CONCLUSION: This study challenges the concept that H. pylori may be a risk factor for head and neck squamous cell carcinoma. This article is protected by copyright. All rights reserved.

Statistics

Altmetrics

Downloads

18 downloads since deposited on 29 Jan 2015
7 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
04 Faculty of Medicine > Institute of Medical Microbiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2016
Deposited On:29 Jan 2015 14:29
Last Modified:22 Apr 2016 01:00
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1043-3074
Additional Information:This is the accepted version of the following article: [Morand, Grégoire B; Fellmann, Jonas; Laske, Roman D; Weisert, Jan U; Soltermann, Alex; Zbinden, Reinhard; Probst, Rudolf; Huber, Gerhard F (2014). Detection of Helicobacter pylori in head and neck cancer patients: Results from a prospective comparative study combining serology, PCR, and rapid urease test. Head and Neck:Epub ahead of print.], which has been published in final form at [http://onlinelibrary.wiley.com/doi/10.1002/hed.23958/abstract].
Publisher DOI:https://doi.org/10.1002/hed.23958
PubMed ID:25522348

Download

Preview Icon on Download
Preview
Content: Accepted Version
Filetype: PDF
Size: 638kB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations