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Detection of Helicobacter pylori in head and neck cancer patients: Results from a prospective comparative study combining serology, PCR, and rapid urease test


Morand, Grégoire B; Fellmann, Jonas; Laske, Roman D; Weisert, Jan U; Soltermann, Alex; Zbinden, Reinhard; Probst, Rudolf; Huber, Gerhard F (2016). Detection of Helicobacter pylori in head and neck cancer patients: Results from a prospective comparative study combining serology, PCR, and rapid urease test. Head and Neck, 38(5):769-774.

Abstract

BACKGROUND: The goal of this study was to evaluate prospectively the presence and impact of the gastric carcinogen Helicobacter pylori in the upper aerodigestive tract. Previous studies suggested it could represent a risk factor for head and neck squamous cell carcinoma.
METHODS: Serology, rapid urease test, and quantitative polymerase chain reaction (qPCR) for H. pylori were performed in head and neck cancer patients (N=56) and cancer-free controls (N=90). Comparison between groups was done using logistic regression analysis.
RESULTS: Rates of positive serology and rapid urease test did not differ between the two groups in logistic regression analysis (P=0.677 and P=0.633, respectively). Birth in a developing country and age above 50 years old were predictors of positive serology (P<0.001 and P=0.040, respectively). Using qPCR, no biopsy showed presence of H.pylori.
CONCLUSION: This study challenges the concept that H. pylori may be a risk factor for head and neck squamous cell carcinoma. This article is protected by copyright. All rights reserved.

Abstract

BACKGROUND: The goal of this study was to evaluate prospectively the presence and impact of the gastric carcinogen Helicobacter pylori in the upper aerodigestive tract. Previous studies suggested it could represent a risk factor for head and neck squamous cell carcinoma.
METHODS: Serology, rapid urease test, and quantitative polymerase chain reaction (qPCR) for H. pylori were performed in head and neck cancer patients (N=56) and cancer-free controls (N=90). Comparison between groups was done using logistic regression analysis.
RESULTS: Rates of positive serology and rapid urease test did not differ between the two groups in logistic regression analysis (P=0.677 and P=0.633, respectively). Birth in a developing country and age above 50 years old were predictors of positive serology (P<0.001 and P=0.040, respectively). Using qPCR, no biopsy showed presence of H.pylori.
CONCLUSION: This study challenges the concept that H. pylori may be a risk factor for head and neck squamous cell carcinoma. This article is protected by copyright. All rights reserved.

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
04 Faculty of Medicine > Institute of Medical Microbiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2016
Deposited On:29 Jan 2015 14:29
Last Modified:02 Feb 2018 09:34
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1043-3074
Additional Information:This is the accepted version of the following article: [Morand, Grégoire B; Fellmann, Jonas; Laske, Roman D; Weisert, Jan U; Soltermann, Alex; Zbinden, Reinhard; Probst, Rudolf; Huber, Gerhard F (2014). Detection of Helicobacter pylori in head and neck cancer patients: Results from a prospective comparative study combining serology, PCR, and rapid urease test. Head and Neck:Epub ahead of print.], which has been published in final form at [http://onlinelibrary.wiley.com/doi/10.1002/hed.23958/abstract].
OA Status:Green
Publisher DOI:https://doi.org/10.1002/hed.23958
PubMed ID:25522348

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