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Genome-wide profiling to analyze the effects of high fat diet induced obesity on renal gene expression in mouse with reduced renal mass


Gai, Zhibo (2014). Genome-wide profiling to analyze the effects of high fat diet induced obesity on renal gene expression in mouse with reduced renal mass. Genomics Data, 2:42-43.

Abstract

To assess the relationship between a reduced nephron number and a particular susceptibility to obesity-induced renal damage, mice underwent uninephrectomy (UNX) followed by either normal chow or high-fat diet (HFD) and were compared with sham-operated control mice. Analysis of gene expression in the mouse kidney by whole genome microarrays indicated that high fat diet led to more changes in gene expression than uninephrectomy. However, the combination of UNX and HFD additionally altered the effects of obesity on gene expression pattern. Here we describe in details the contents and quality controls for the gene expression and related results associated with the data uploaded to Gene Expression Omnibus (accession number GSE53996).

Abstract

To assess the relationship between a reduced nephron number and a particular susceptibility to obesity-induced renal damage, mice underwent uninephrectomy (UNX) followed by either normal chow or high-fat diet (HFD) and were compared with sham-operated control mice. Analysis of gene expression in the mouse kidney by whole genome microarrays indicated that high fat diet led to more changes in gene expression than uninephrectomy. However, the combination of UNX and HFD additionally altered the effects of obesity on gene expression pattern. Here we describe in details the contents and quality controls for the gene expression and related results associated with the data uploaded to Gene Expression Omnibus (accession number GSE53996).

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Chronic kidney failure; Gene regulation; High fat diet; Microarray
Language:English
Date:2014
Deposited On:05 Feb 2015 17:13
Last Modified:04 Sep 2017 17:25
Publisher:Elsevier
ISSN:2213-5960
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.gdata.2014.02.002
PubMed ID:26484066

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Licence: Creative Commons: Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0)

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