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Out-of body experiences: cell-free cell death.


Hengartner, M O (1995). Out-of body experiences: cell-free cell death. BioEssays, 17(6):549-552.

Abstract

Apoptosis (programmed cell death) is an evolutionarily conserved cellular process, important for development and homeostasis. Most apoptotic cells share a common set of morphological and physiological characteristics that distinguish them from necrotic deaths. While genetic studies have indicated that these characteristic changes result from the activation of an endogenous 'suicide program', little is known about the nature of this program and the molecular events underlying these changes. Two recent papers describing cell-free extracts that reproduce several of the characteristic changes observed in apoptotic cells promise to make these phenomena accessible to biochemical analysis.

Abstract

Apoptosis (programmed cell death) is an evolutionarily conserved cellular process, important for development and homeostasis. Most apoptotic cells share a common set of morphological and physiological characteristics that distinguish them from necrotic deaths. While genetic studies have indicated that these characteristic changes result from the activation of an endogenous 'suicide program', little is known about the nature of this program and the molecular events underlying these changes. Two recent papers describing cell-free extracts that reproduce several of the characteristic changes observed in apoptotic cells promise to make these phenomena accessible to biochemical analysis.

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3 citations in Web of Science®
3 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:1 June 1995
Deposited On:11 Feb 2008 12:20
Last Modified:05 Apr 2016 12:17
Publisher:Wiley-Blackwell
ISSN:0265-9247
Publisher DOI:https://doi.org/10.1002/bies.950170612
PubMed ID:7575497

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