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High-density lipoprotein: Vascular protective effects, dysfunction, and potential as therapeutic target


Lüscher, Thomas F; Landmesser, Ulf; von Eckardstein, Arnold; Fogelman, Alan M (2014). High-density lipoprotein: Vascular protective effects, dysfunction, and potential as therapeutic target. Circulation Research, 114(1):171-182.

Abstract

High-density lipoprotein (HDL) is a complex mixture of lipoproteins that is associated with many minor proteins and lipids that influence the function of HDL. Although HDL is a promising marker and potential therapeutic target based on its epidemiological data and the effects of healthy HDL in vitro in endothelial cells and macrophages, as well as based on infusion studies of reconstituted HDL in patients with hypercholesterolemia, it remains still uncertain whether or not HDL cholesterol-raising drugs will improve outcomes. Recent studies suggest that HDL becomes modified in patients with coronary artery disease or acute coronary syndrome because of oxidative processes that result in alterations in its proteome composition (proteome remodelling) leading to HDL dysfunction.

Abstract

High-density lipoprotein (HDL) is a complex mixture of lipoproteins that is associated with many minor proteins and lipids that influence the function of HDL. Although HDL is a promising marker and potential therapeutic target based on its epidemiological data and the effects of healthy HDL in vitro in endothelial cells and macrophages, as well as based on infusion studies of reconstituted HDL in patients with hypercholesterolemia, it remains still uncertain whether or not HDL cholesterol-raising drugs will improve outcomes. Recent studies suggest that HDL becomes modified in patients with coronary artery disease or acute coronary syndrome because of oxidative processes that result in alterations in its proteome composition (proteome remodelling) leading to HDL dysfunction.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Clinical Chemistry
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
Dewey Decimal Classification:610 Medicine & health
540 Chemistry
Language:English
Date:3 January 2014
Deposited On:28 Jan 2015 12:19
Last Modified:05 Apr 2016 18:50
Publisher:Lippincott Williams & Wilkins
ISSN:0009-7330
Publisher DOI:https://doi.org/10.1161/CIRCRESAHA.114.300935
PubMed ID:24385510

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