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Visual problem and low back pain as initial manifestation of multiple myeloma complicating pre-existing systemic sclerosis


Owlia, Mohammad Bagher; Distler, Oliver; Foratyazdi, Mohammad; Akhtari, Mojtaba (2014). Visual problem and low back pain as initial manifestation of multiple myeloma complicating pre-existing systemic sclerosis. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 24 Suppl:S29-31.

Abstract

Some connective tissue diseases are associated with an increased risk of developing neoplastic disorders. Association of rheumatoid arthritis and systemic lupus erythematosus with lymphoma, and of dermatomyositis with different malignancies including ovarian and lung cancer has been reported in the literature. Here, we describe a 58 years old man with systemic sclerosis (SSc) for 15 years who developed severe lumbar pain when he was admitted for intravenous infusion of prostaglandin E1 for his fingertip ulcers. He was found to have abnormal skeletal imaging. Laboratory tests including bone marrow aspiration and biopsy determined multiple myeloma causing extensive bony infiltration. The patient expired after two cycles of VAD and Bortezomide chemotherapy.

Abstract

Some connective tissue diseases are associated with an increased risk of developing neoplastic disorders. Association of rheumatoid arthritis and systemic lupus erythematosus with lymphoma, and of dermatomyositis with different malignancies including ovarian and lung cancer has been reported in the literature. Here, we describe a 58 years old man with systemic sclerosis (SSc) for 15 years who developed severe lumbar pain when he was admitted for intravenous infusion of prostaglandin E1 for his fingertip ulcers. He was found to have abnormal skeletal imaging. Laboratory tests including bone marrow aspiration and biopsy determined multiple myeloma causing extensive bony infiltration. The patient expired after two cycles of VAD and Bortezomide chemotherapy.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:March 2014
Deposited On:11 Feb 2015 15:14
Last Modified:08 Dec 2017 10:29
Publisher:College of Physicians & Surgeons Pakistan
ISSN:1022-386X
PubMed ID:24717997

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