# A novel $^{99m}$Tc labelling strategy for the development of silica based particles for medical applications

Wuillemin, Michel A; Stuber, Wanda T; Fox, Thomas; Reber, Michael J; Brühwiler, Dominik; Alberto, Roger; Braband, Henrik (2014). A novel $^{99m}$Tc labelling strategy for the development of silica based particles for medical applications. Dalton Transactions, 43(11):4260.

## Abstract

The reaction of high-valent fac-{$^{99m}$TcO$_3$}+ complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By applying norbornene as a coupling unit the (3 + 2)-cycloaddition reaction proceeds stereoselectively and with high reaction rates.

## Abstract

The reaction of high-valent fac-{$^{99m}$TcO$_3$}+ complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By applying norbornene as a coupling unit the (3 + 2)-cycloaddition reaction proceeds stereoselectively and with high reaction rates.

## Statistics

### Citations

3 citations in Web of Science®
1 citation in Scopus®
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## Additional indexing

Item Type: Journal Article, refereed, original work 07 Faculty of Science > Department of Chemistry 540 Chemistry English 2014 20 Feb 2015 09:49 05 Apr 2016 18:56 RSC Publishing 1477-9226 https://doi.org/10.1039/c3dt53019a

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