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A novel $^{99m}$Tc labelling strategy for the development of silica based particles for medical applications


Wuillemin, Michel A; Stuber, Wanda T; Fox, Thomas; Reber, Michael J; Brühwiler, Dominik; Alberto, Roger; Braband, Henrik (2014). A novel $^{99m}$Tc labelling strategy for the development of silica based particles for medical applications. Dalton Transactions, 43(11):4260.

Abstract

The reaction of high-valent fac-{$^{99m}$TcO$_3$}+ complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By applying norbornene as a coupling unit the (3 + 2)-cycloaddition reaction proceeds stereoselectively and with high reaction rates.

Abstract

The reaction of high-valent fac-{$^{99m}$TcO$_3$}+ complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By applying norbornene as a coupling unit the (3 + 2)-cycloaddition reaction proceeds stereoselectively and with high reaction rates.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:2014
Deposited On:20 Feb 2015 09:49
Last Modified:08 Dec 2017 11:05
Publisher:RSC Publishing
ISSN:1477-9226
Publisher DOI:https://doi.org/10.1039/c3dt53019a

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