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Evaluation of the use and handling of three different pen systems considered for in vitro fertilization treatment


Imthurn, Bruno; McVeigh, Enda; Stiller, Ruth; Arnold, Michelle; Pringle, Fiona; Irps, Charlotte; Rettenbacher, Manfred (2014). Evaluation of the use and handling of three different pen systems considered for in vitro fertilization treatment. Expert Opinion on Drug Delivery, 11(12):1859-1864.

Abstract

OBJECTIVE The objective of this study was to assess and compare the features of the Bemfola, Gonal-f and Puregon injection pens. METHODS Females who intended to undergo hormonal treatment received the three different pens in a randomized, consecutive sequence. For each of the pens, the potential patients completed an Injection Pen Assessment Questionnaire, as well as a questionnaire comparing the handling, convenience and preference among the three pens. RESULTS The mean score on the visual analogue scale (VAS) for the Bemfola pen (BP) was 77.8 ± 14.0; for the Puregon pen (PP), 72.1 ± 12.4; and for the Gonal-f pen (GP), 68.6 ± 16.4. The BP was superior to both competitor devices in pen size, inconspicuousness, ease of use and dose changing; no significant differences to both competitor pens were observed in the way the pen looks, the way the pen feels and the ease of injection of the volume. The 'overall' assessment was significantly better for the BP when compared to the GP (p = 0.0019), while no significant difference was observed between the BP and the PP. CONCLUSIONS This study demonstrated significantly higher ratings for pen size, inconspicuousness, ease of use and dose adjustment for the BP compared to other marketed pens.

Abstract

OBJECTIVE The objective of this study was to assess and compare the features of the Bemfola, Gonal-f and Puregon injection pens. METHODS Females who intended to undergo hormonal treatment received the three different pens in a randomized, consecutive sequence. For each of the pens, the potential patients completed an Injection Pen Assessment Questionnaire, as well as a questionnaire comparing the handling, convenience and preference among the three pens. RESULTS The mean score on the visual analogue scale (VAS) for the Bemfola pen (BP) was 77.8 ± 14.0; for the Puregon pen (PP), 72.1 ± 12.4; and for the Gonal-f pen (GP), 68.6 ± 16.4. The BP was superior to both competitor devices in pen size, inconspicuousness, ease of use and dose changing; no significant differences to both competitor pens were observed in the way the pen looks, the way the pen feels and the ease of injection of the volume. The 'overall' assessment was significantly better for the BP when compared to the GP (p = 0.0019), while no significant difference was observed between the BP and the PP. CONCLUSIONS This study demonstrated significantly higher ratings for pen size, inconspicuousness, ease of use and dose adjustment for the BP compared to other marketed pens.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Reproductive Endocrinology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:December 2014
Deposited On:03 Feb 2015 14:15
Last Modified:08 Dec 2017 11:14
Publisher:Informa Healthcare
ISSN:1742-5247
Publisher DOI:https://doi.org/10.1517/17425247.2014.965676
PubMed ID:25325925

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