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Balgacyclamides, Antiplasmodial Heterocyclic Peptides fromMicrocystis aeruguinosaEAWAG 251


Portmann, Cyril; Sieber, Simon; Wirthensohn, Silvan; Blom, Judith F; Da Silva, Laeticia; Baudat, Emilie; Kaiser, Marcel; Brun, Reto; Gademann, Karl (2014). Balgacyclamides, Antiplasmodial Heterocyclic Peptides fromMicrocystis aeruguinosaEAWAG 251. Journal of natural products, 77(3):557-562.

Abstract

The isolation and structural characterization of three new heterocyclic and macrocyclic peptides, balgacyclamides A-C, from Microcystis aeruginosa EAWAG 251 are reported. The constitutions were determined by 2D-NMR methods and mass spectrometry, and the configurations were assigned after ozonolysis and hydrolysis by HPLC-MS methods using Marfey's method as well as GC-MS using authentic standards. Balgacyclamides A and B were active against Plasmodium falciparum K1 in the low micromolar range, while displaying low toxicity to rat myoblasts.

Abstract

The isolation and structural characterization of three new heterocyclic and macrocyclic peptides, balgacyclamides A-C, from Microcystis aeruginosa EAWAG 251 are reported. The constitutions were determined by 2D-NMR methods and mass spectrometry, and the configurations were assigned after ozonolysis and hydrolysis by HPLC-MS methods using Marfey's method as well as GC-MS using authentic standards. Balgacyclamides A and B were active against Plasmodium falciparum K1 in the low micromolar range, while displaying low toxicity to rat myoblasts.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Plant and Microbial Biology
Dewey Decimal Classification:580 Plants (Botany)
Language:English
Date:2014
Deposited On:20 Feb 2015 11:56
Last Modified:14 Feb 2018 23:05
Publisher:American Chemical Society
ISSN:0163-3864
Additional Information:This document is the Accepted Manuscript version of a Published Work that appeared in final form in [J. Nat. Prod], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/np400814w.
OA Status:Green
Publisher DOI:https://doi.org/10.1021/np400814w
PubMed ID:24392715

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