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Could hyperthermia with proton therapy mimic carbon ion therapy? Exploring a thermo-radiobiological rationale


Datta, N; Puric, E; Schneider, R; Weber, D C; Rogers, S; Bodis, S (2014). Could hyperthermia with proton therapy mimic carbon ion therapy? Exploring a thermo-radiobiological rationale. International Journal of Hyperthermia, 30(7):524-530.

Abstract

Hyperthermia has been conventionally used in conjunction with photon beam irradiation. With a gradual increase in particle therapy facilities worldwide, this paper explores the physical, thermal and radiobiological implications of using a combination of hyperthermia with proton beam therapy. Hyperthermia is known to exhibit radiobiological features similar to those of high linear energy transfer radiation. Protons have many of the physical dose distribution properties of (12)C ion therapy. Thus, the thermo-radiobiological advantages of hyperthermia coupled with the physical dose distribution advantages of proton beams could possibly mimic (12)C ion therapy.

Abstract

Hyperthermia has been conventionally used in conjunction with photon beam irradiation. With a gradual increase in particle therapy facilities worldwide, this paper explores the physical, thermal and radiobiological implications of using a combination of hyperthermia with proton beam therapy. Hyperthermia is known to exhibit radiobiological features similar to those of high linear energy transfer radiation. Protons have many of the physical dose distribution properties of (12)C ion therapy. Thus, the thermo-radiobiological advantages of hyperthermia coupled with the physical dose distribution advantages of proton beams could possibly mimic (12)C ion therapy.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Radiation Oncology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:November 2014
Deposited On:19 Feb 2015 14:38
Last Modified:14 Feb 2018 23:05
Publisher:Informa Healthcare
ISSN:0265-6736
OA Status:Closed
Publisher DOI:https://doi.org/10.3109/02656736.2014.963703
PubMed ID:25314095

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