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cosmiq - COmbining Single Masses Into Quantities


Fischer, David; Panse, Christian; Laczko, Endre (2014). cosmiq - COmbining Single Masses Into Quantities. Bioconductor R Package v1.1.0 BioC 3.0, University of Zurich.

Abstract

cosmiq is a tool for the preprocessing of liquid- or gas - chromatography mass spectrometry (LCMS/GCMS) data with a focus on metabolomics or lipidomics applications. To improve the detection of low abundant signals, cosmiq generates master maps of the mZ/RT space from all acquired runs before a peak detection algorithm is applied. The result is a more robust identification and quantification of low-intensity MS signals compared to conventional approaches where peak picking is performed in each LCMS/GCMS file separately. The cosmiq package builds on the xcmsSet object structure and can be therefore integrated well with the package xcms as an alternative preprocessing step.

Abstract

cosmiq is a tool for the preprocessing of liquid- or gas - chromatography mass spectrometry (LCMS/GCMS) data with a focus on metabolomics or lipidomics applications. To improve the detection of low abundant signals, cosmiq generates master maps of the mZ/RT space from all acquired runs before a peak detection algorithm is applied. The result is a more robust identification and quantification of low-intensity MS signals compared to conventional approaches where peak picking is performed in each LCMS/GCMS file separately. The cosmiq package builds on the xcmsSet object structure and can be therefore integrated well with the package xcms as an alternative preprocessing step.

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Item Type:Working Paper
Communities & Collections:04 Faculty of Medicine > Functional Genomics Center Zurich
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:6 December 2014
Deposited On:24 Feb 2015 16:56
Last Modified:05 Apr 2016 19:01
Series Name:Bioconductor R Package v1.1.0
Free access at:Official URL. An embargo period may apply.
Official URL:http://www.bioconductor.org/packages/devel/bioc/html/cosmiq.html

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