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Letter to the Editor


Hersberger, Martin (2015). Letter to the Editor. Gene, 558(2):299.

Abstract

In the publication “Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants” (Gene 531 (2013) 71–77) the authors perform six meta-analyses on single nucleotide polymorphisms located in different genes for an association with coronary heart disease (CHD). One of these genes is ALOX15 for which two large studies have been included in the analysis. While both of these studies investigated the association of the functional polymorphism rs34210653 with CHD, the authors interchanged the numbers of cases and controls in their analysis for one of the publications (Atherosclerosis. 2009 Jul;205(1):192–6). In contrast to what is displayed in their meta-analysis, this study included 2028 controls and 477 cases and showed a non-significant OR for CHD of 1.73 (CI 0.43–2.3). This changes the interpretation of the results dramatically because now all three large sub-studies investigating the association of rs34210653 with CHD reveal similar although sometimes non-significant risk increases for the minor allele.

Abstract

In the publication “Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants” (Gene 531 (2013) 71–77) the authors perform six meta-analyses on single nucleotide polymorphisms located in different genes for an association with coronary heart disease (CHD). One of these genes is ALOX15 for which two large studies have been included in the analysis. While both of these studies investigated the association of the functional polymorphism rs34210653 with CHD, the authors interchanged the numbers of cases and controls in their analysis for one of the publications (Atherosclerosis. 2009 Jul;205(1):192–6). In contrast to what is displayed in their meta-analysis, this study included 2028 controls and 477 cases and showed a non-significant OR for CHD of 1.73 (CI 0.43–2.3). This changes the interpretation of the results dramatically because now all three large sub-studies investigating the association of rs34210653 with CHD reveal similar although sometimes non-significant risk increases for the minor allele.

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Additional indexing

Item Type:Journal Article, not refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2015
Deposited On:26 Feb 2015 08:03
Last Modified:08 Dec 2017 12:04
Publisher:Elsevier
ISSN:0378-1119
Additional Information:Letter to the Editor
Publisher DOI:https://doi.org/10.1016/j.gene.2015.01.017
PubMed ID:25592824

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