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Mono- and dinuclear metal complexes containing the 1,5,9-triazacyclododecane ([12]aneN3) unit and their interaction with DNA


Medina-Molner, Alfredo; Rohner, Melanie; Pandiarajan, Devaraj; Spingler, Bernhard (2015). Mono- and dinuclear metal complexes containing the 1,5,9-triazacyclododecane ([12]aneN3) unit and their interaction with DNA. Dalton Transactions, 44(8):3664-3672.

Abstract

The ability of mononucleating and dinucleating macrocylic polyamines and their novel nickel, copper and zinc complexes to induce the left-handed form of poly d(GC) was evaluated. The influence of the nuclearity, the presence or absence of metals ions, the linker length in the case of dinucleating ligands and the metal ion was determined. Almost all dinuclear metal complexes efficiently induced Z-DNA, the zinc ones being the least and the copper ones the most efficient ones. Additionally, the X-ray structures of three dinuclear metal complexes and one partially protonated ligand could be determined.

Abstract

The ability of mononucleating and dinucleating macrocylic polyamines and their novel nickel, copper and zinc complexes to induce the left-handed form of poly d(GC) was evaluated. The influence of the nuclearity, the presence or absence of metals ions, the linker length in the case of dinucleating ligands and the metal ion was determined. Almost all dinuclear metal complexes efficiently induced Z-DNA, the zinc ones being the least and the copper ones the most efficient ones. Additionally, the X-ray structures of three dinuclear metal complexes and one partially protonated ligand could be determined.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:February 2015
Deposited On:12 Mar 2015 09:16
Last Modified:05 Apr 2016 19:05
Publisher:RSC Publishing
ISSN:1477-9226
Publisher DOI:https://doi.org/10.1039/c4dt02713b

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