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Effects of vitamin D in the elderly population: current status and perspectives


Bruyère, Olivier; Cavalier, Etienne; Souberbielle, Jean-Claude; Bischoff-Ferrari, Heike A; Beaudart, Charlotte; Buckinx, Fanny; Reginster, Jean-Yves; Rizzoli, René (2014). Effects of vitamin D in the elderly population: current status and perspectives. Archives of Public Health, 72(1):32.

Abstract

Besides its well-known effect on bone metabolism, recent researches suggest that vitamin D may also play a role in the muscular, immune, endocrine, and central nervous systems. Double-blind RCTs support vitamin D supplementation at a dose of 800 IU per day for the prevention of falls and fractures in the senior population. Ecological, case-control and cohort studies have suggested that high vitamin D levels were associated with a reduced risk of autoimmune diseases, type 2 diabetes, cardio-vascular diseases and cancer but large clinical trials are lacking today to provide solid evidence of a vitamin D benefit beyond bone health. At last, the optimal dose, route of administration, dosing interval and duration of vitamin D supplementation at a specific target dose beyond the prevention of vitamin D deficiency need to be further investigated.

Abstract

Besides its well-known effect on bone metabolism, recent researches suggest that vitamin D may also play a role in the muscular, immune, endocrine, and central nervous systems. Double-blind RCTs support vitamin D supplementation at a dose of 800 IU per day for the prevention of falls and fractures in the senior population. Ecological, case-control and cohort studies have suggested that high vitamin D levels were associated with a reduced risk of autoimmune diseases, type 2 diabetes, cardio-vascular diseases and cancer but large clinical trials are lacking today to provide solid evidence of a vitamin D benefit beyond bone health. At last, the optimal dose, route of administration, dosing interval and duration of vitamin D supplementation at a specific target dose beyond the prevention of vitamin D deficiency need to be further investigated.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Geriatric Medicine
Dewey Decimal Classification:Unspecified
Language:English
Date:2014
Deposited On:26 Feb 2015 14:58
Last Modified:03 Aug 2017 16:42
Publisher:Archives Belges de Médecine Sociale
ISSN:0778-7367
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1186/2049-3258-72-32
PubMed ID:25279143

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