Header

UZH-Logo

Maintenance Infos

Neurobiological disease etiology and inheritance: an epigenetic perspective


Saab, B J; Mansuy, I M (2014). Neurobiological disease etiology and inheritance: an epigenetic perspective. The Journal of Experimental Biology, 217:94-101.

Abstract

Epigenetic marks in mammals are essential to properly control the activity of the genome. They are dynamically regulated during development and adulthood, and can be modulated by environmental factors throughout life. Changes in the epigenetic profile of a cell can be positive and favor the expression of advantageous genes such as those linked to cell signaling and tumor suppression. However, they can also be detrimental and alter the functions of important genes, thereby leading to disease. Recent evidence has further highlighted that some epigenetic marks can be maintained across meiosis and be transmitted to the subsequent generation to reprogram developmental and cellular features. This short review describes current knowledge on the potential impact of epigenetic processes activated by environmental factors on the inheritance of neurobiological disease risk. In addition, the potential adaptive value of epigenetic inheritance, and relevant current and future questions are discussed.

Abstract

Epigenetic marks in mammals are essential to properly control the activity of the genome. They are dynamically regulated during development and adulthood, and can be modulated by environmental factors throughout life. Changes in the epigenetic profile of a cell can be positive and favor the expression of advantageous genes such as those linked to cell signaling and tumor suppression. However, they can also be detrimental and alter the functions of important genes, thereby leading to disease. Recent evidence has further highlighted that some epigenetic marks can be maintained across meiosis and be transmitted to the subsequent generation to reprogram developmental and cellular features. This short review describes current knowledge on the potential impact of epigenetic processes activated by environmental factors on the inheritance of neurobiological disease risk. In addition, the potential adaptive value of epigenetic inheritance, and relevant current and future questions are discussed.

Statistics

Citations

Dimensions.ai Metrics
7 citations in Web of Science®
9 citations in Scopus®
9 citations in Microsoft Academic
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:1 January 2014
Deposited On:23 Feb 2015 15:26
Last Modified:14 Feb 2018 23:23
Publisher:The Company of Biologists Ltd.
ISSN:1477-9145
OA Status:Closed
Publisher DOI:https://doi.org/10.1242/​jeb.089995
Official URL:http://jeb.biologists.org/content/217/1/94.abstract

Download

Full text not available from this repository.
View at publisher