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Zif268/Egr1 gain of function facilitates hippocampal synaptic plasticity and long-term spatial recognition memory


Penke, Z; Morice, E; Veyrac, A; Gros, A; Chagneau, C; LeBlanc, P; Samson, N; Baumgärtel, K; Mansuy, I M; Davis, S; Laroche, S (2014). Zif268/Egr1 gain of function facilitates hippocampal synaptic plasticity and long-term spatial recognition memory. Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 369:20130159.

Abstract

It is well established that Zif268/Egr1, a member of the
Egr family of transcription factors, is critical for the consolidation of several forms of memory; however, it is as yet uncertain whether increasing expression of Zif268 in neurons can facilitate memory formation. Here, we used an inducible transgenic mouse model to specifically induce Zif268 overexpression in forebrain neurons and examined the effect on recognition memory and hippocampal synaptic transmission and plasticity. We found that Zif268 overexpression during the establishment of memory for objects did not change the ability to form a long-term memory of objects, but enhanced the capacity to form a long-term memory of the spatial location of objects. This enhancement was paralleled by increased long-term potentiation in the dentate gyrus of the hippocampus and by increased activity-dependent expression of Zif268 and selected Zif268 target genes. These results provide novel evidence that transcriptional mechanisms engaging Zif268 contribute to determining the strength of newly encoded memories.

Abstract

It is well established that Zif268/Egr1, a member of the
Egr family of transcription factors, is critical for the consolidation of several forms of memory; however, it is as yet uncertain whether increasing expression of Zif268 in neurons can facilitate memory formation. Here, we used an inducible transgenic mouse model to specifically induce Zif268 overexpression in forebrain neurons and examined the effect on recognition memory and hippocampal synaptic transmission and plasticity. We found that Zif268 overexpression during the establishment of memory for objects did not change the ability to form a long-term memory of objects, but enhanced the capacity to form a long-term memory of the spatial location of objects. This enhancement was paralleled by increased long-term potentiation in the dentate gyrus of the hippocampus and by increased activity-dependent expression of Zif268 and selected Zif268 target genes. These results provide novel evidence that transcriptional mechanisms engaging Zif268 contribute to determining the strength of newly encoded memories.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2014
Deposited On:23 Feb 2015 15:48
Last Modified:08 Dec 2017 12:15
Publisher:Royal Society Publishing
ISSN:0962-8436
Additional Information:Free accessible after 12 months (biological sciences).
Publisher DOI:https://doi.org/10.1098/rstb.2013.0159
PubMed ID:24298160

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