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Sensory evoked potentials of the bladder and urethra in middle-aged women: the effect of age


Gregorini, Flavia; Knüpfer, Stephanie; Liechti, Martina D; Schubert, Martin; Curt, Armin; Kessler, Thomas M; Mehnert, Ulrich (2015). Sensory evoked potentials of the bladder and urethra in middle-aged women: the effect of age. BJU International, 115:18-25.

Abstract

OBJECTIVES To investigate feasibility, reproducibility and age dependency of sensory evoked cortical potentials (SEPs) after electrical stimulation of different localizations in the lower urinary tract (LUT) in a cohort of middle-aged healthy women. SUBJECTS AND METHODS In a group of ten healthy middle-aged women (mean height: 165±5cm; mean age: 43±6 years), electrical stimulation (0.5 and 3Hz) was applied to bladder dome, trigone, proximal and distal urethra. SEPs were recorded at the Cz electrode with reference to Fz. All measurements were repeated three times with an interval of three to five weeks. Current perception thresholds (CPT), SEP latencies and amplitudes were analysed. Results were compared to a group of younger women published previously. RESULTS LUT SEPs demonstrated 2 positive (P1, P2) and 1 negative peak (N1). The mean N1 latency was 108.9±7.8ms, 116.2±10.7ms, 113.2±13.4ms, and 131.3±35.6ms for bladder dome, trigone, proximal and distal urethra, respectively. N1 latencies - except for the distal urethra - were significantly shorter compared to younger women. Taking all data, i.e. young and middle-aged women, into account, there was a significant negative correlation between the variable age and CPT/dome (r = -0.462, p = 0.04) and N1 latency/dome (r = -0.605, p = 0.005) and a significant positive correlation between the variable age and N1P2 amplitude/dome (r = 0.542, p = 0.014). CONCLUSION LUT-SEPs can be induced in middle-aged women with reliable N1 responses. Unexpectedly, N1 responses reveal a shortening with increasing age particularly when compared to younger women. Changes in sensory afferents may be explained by age related qualitative reorganizations within the urothelium and suburothelium potentially altering afferent nerve excitability and may have an impact on the development of non-neurological LUT disorders (e.g. overactive bladder) in women.

Abstract

OBJECTIVES To investigate feasibility, reproducibility and age dependency of sensory evoked cortical potentials (SEPs) after electrical stimulation of different localizations in the lower urinary tract (LUT) in a cohort of middle-aged healthy women. SUBJECTS AND METHODS In a group of ten healthy middle-aged women (mean height: 165±5cm; mean age: 43±6 years), electrical stimulation (0.5 and 3Hz) was applied to bladder dome, trigone, proximal and distal urethra. SEPs were recorded at the Cz electrode with reference to Fz. All measurements were repeated three times with an interval of three to five weeks. Current perception thresholds (CPT), SEP latencies and amplitudes were analysed. Results were compared to a group of younger women published previously. RESULTS LUT SEPs demonstrated 2 positive (P1, P2) and 1 negative peak (N1). The mean N1 latency was 108.9±7.8ms, 116.2±10.7ms, 113.2±13.4ms, and 131.3±35.6ms for bladder dome, trigone, proximal and distal urethra, respectively. N1 latencies - except for the distal urethra - were significantly shorter compared to younger women. Taking all data, i.e. young and middle-aged women, into account, there was a significant negative correlation between the variable age and CPT/dome (r = -0.462, p = 0.04) and N1 latency/dome (r = -0.605, p = 0.005) and a significant positive correlation between the variable age and N1P2 amplitude/dome (r = 0.542, p = 0.014). CONCLUSION LUT-SEPs can be induced in middle-aged women with reliable N1 responses. Unexpectedly, N1 responses reveal a shortening with increasing age particularly when compared to younger women. Changes in sensory afferents may be explained by age related qualitative reorganizations within the urothelium and suburothelium potentially altering afferent nerve excitability and may have an impact on the development of non-neurological LUT disorders (e.g. overactive bladder) in women.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Balgrist University Hospital, Swiss Spinal Cord Injury Center
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:28 January 2015
Deposited On:27 Feb 2015 12:54
Last Modified:05 Apr 2016 19:08
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1464-4096
Publisher DOI:https://doi.org/10.1111/bju.13066
PubMed ID:25626360

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