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Powerful Drosophila screens that paved the wingless pathway


Jenny, Fabian Heinz; Basler, Konrad (2015). Powerful Drosophila screens that paved the wingless pathway. Fly, 8(4):218-225.

Abstract

The Wnt/Wingless (Wg) signaling cascade controls a number of biological processes in animal development and adult life; aberrant Wnt/Wg signaling can cause diseases. In the 1980s genes were discovered that encode core Wnt/Wg pathway components: their mutant phenotypes were similar and an outline of a signaling cascade emerged. Over the years our knowledge of this important signaling system increased and more components were uncovered that are instrumental for Wnt/Wg secretion and transduction. Here we provide an overview of these discoveries, the technologies involved, with a particular focus on the important role Drosophila screens played in this process.

Abstract

The Wnt/Wingless (Wg) signaling cascade controls a number of biological processes in animal development and adult life; aberrant Wnt/Wg signaling can cause diseases. In the 1980s genes were discovered that encode core Wnt/Wg pathway components: their mutant phenotypes were similar and an outline of a signaling cascade emerged. Over the years our knowledge of this important signaling system increased and more components were uncovered that are instrumental for Wnt/Wg secretion and transduction. Here we provide an overview of these discoveries, the technologies involved, with a particular focus on the important role Drosophila screens played in this process.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:7 January 2015
Deposited On:09 Apr 2015 06:39
Last Modified:08 Dec 2017 12:46
Publisher:Taylor & Francis
ISSN:1933-6934
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.4161/19336934.2014.985988
PubMed ID:25565425

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