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Oral infections: clinical and biological perspectives


Belibasakis, Georgios N; Mylonakis, Eleftherios (2015). Oral infections: clinical and biological perspectives. Virulence, 6(3):173-176.

Abstract

The oral cavity is a specialized ecological niche of the human body and forms a continuum with the digestive and respiratory system. The vastly diverse endogenous microbiota of the oral cavity is collectively referred to as the "oral microbiome". It has been, and continues to be, explored by numerous cultivation or culture-independent methods, yielding more that 600 individual taxa (1) . They show tropism for different microhabitats, but may also show differential associations with oral health or disease. Commensal oral microbiota live in a symbiotic relationship with the host, which is crucial for the maintenance of oral health (2) . Yet, disruption of this tight relationship by various factors will result in dysbiosis, allowing for the survival and establishment of a more virulent pathobiotic polymicrobial community that may impair the efficient immune response (3, 4) . Clinically, these events could manifest as an oral infectious diseases.

Abstract

The oral cavity is a specialized ecological niche of the human body and forms a continuum with the digestive and respiratory system. The vastly diverse endogenous microbiota of the oral cavity is collectively referred to as the "oral microbiome". It has been, and continues to be, explored by numerous cultivation or culture-independent methods, yielding more that 600 individual taxa (1) . They show tropism for different microhabitats, but may also show differential associations with oral health or disease. Commensal oral microbiota live in a symbiotic relationship with the host, which is crucial for the maintenance of oral health (2) . Yet, disruption of this tight relationship by various factors will result in dysbiosis, allowing for the survival and establishment of a more virulent pathobiotic polymicrobial community that may impair the efficient immune response (3, 4) . Clinically, these events could manifest as an oral infectious diseases.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Institute of Oral Biology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 April 2015
Deposited On:16 Apr 2015 08:46
Last Modified:08 Dec 2017 12:48
Publisher:Landes Bioscience
ISSN:2150-5594
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1080/21505594.2015.1025191
PubMed ID:25830413

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