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Regulating cellular oxygen sensing by hydroxylation


Fandrey, Joachim; Gorr, Thomas A; Gassmann, Max (2006). Regulating cellular oxygen sensing by hydroxylation. Cardiovascular Research, 71(4):642-651.

Abstract

Oxygen homeostasis under conditions of limited O2 supply requires hypoxia-dependent gene regulation. The transcription factor complex hypoxia-inducible factor 1 (HIF-1) has been recognized as the master regulator that mediates the adaptational genetic response to ensure restoration of energy supply. This review will focus on the recent advances in understanding the hypoxia-induced cellular response with particular respect to cellular O2 sensing for adequate control of HIF-1 activation.

Abstract

Oxygen homeostasis under conditions of limited O2 supply requires hypoxia-dependent gene regulation. The transcription factor complex hypoxia-inducible factor 1 (HIF-1) has been recognized as the master regulator that mediates the adaptational genetic response to ensure restoration of energy supply. This review will focus on the recent advances in understanding the hypoxia-induced cellular response with particular respect to cellular O2 sensing for adequate control of HIF-1 activation.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
05 Vetsuisse Faculty > Institute of Veterinary Physiology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:1 September 2006
Deposited On:15 Apr 2015 13:34
Last Modified:05 Apr 2016 19:13
Publisher:Oxford University Press
ISSN:0008-6363
Publisher DOI:https://doi.org/10.1016/j.cardiores.2006.05.005
PubMed ID:16780822

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