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The value of18F-FDG-PET/CT imaging in oral cavity cancer patients following surgical reconstruction - Zurich Open Repository and Archive


Müller, Julian; Hüllner, Martin; Strobel, Klaus; Huber, Gerhard F; Burger, Irene A; Haerle, Stephan K (2015). The value of18F-FDG-PET/CT imaging in oral cavity cancer patients following surgical reconstruction. The Laryngoscope, 125(8):1861-1868.

Abstract

OBJECTIVE: Follow-up of patients with oral cavity squamous cell carcinoma (OCSCC) after tumor resection and reconstruction with tissue transfer is challenging. We compared contrast-enhanced computed tomography (ceCT), 18 F-fluorodeoxyglucose-positron emission tomography combined with noncontrast enhanced CT (18 F-FDG-PET/CT), and 18 F-FDG-PET combined with ceCT (18 F-FDG-PET/ceCT) to determine the accuracy for detection of residual/recurrent disease after flap reconstruction for OCSCC.
STUDY DESIGN AND METHODS: Two readers (R1, R2) retrospectively reviewed a total of 27 18 F-FDG-PET/ceCT scans in patients after resection of stage II to IV OCSCC. They recorded the presence of local persistence/recurrence (LR), lymph node metastasis, or distant metastasis independently for ceCT, 18 F-FDG-PET/CT, and 18 F-FDG-PET/ceCT. Histological workup, imaging follow-up, or clinical follow-up served as the standard of reference. Maximum standardized uptake value (SUVmax) was evaluated to discriminate between physiological uptake and LR.
RESULTS: The highest accuracy to detect LR was achieved with 18 F-FDG-PET/ceCT, with a sensitivity/specificity of 88%/89% and 88%/79% for R1 and R2, respectively, as compared to ceCT with 75%/79% for R1 and 88%/68% for R2 and 18 F-FDG-PET/CT with 88%/58% for both R1 and R2. Receiver-operating-characteristic analysis determined a cutoff value for SUVmax of 7.2, yielding a sensitivity and specificity of 75% and 94%, respectively, to distinguish LR from physiological 18 F-FDG uptake.
CONCLUSION: 18 F-FDG-PET/ceCT seems to be the most reliable tool for locoregional surveillance of OCSCC patients after resection and reconstruction.

Abstract

OBJECTIVE: Follow-up of patients with oral cavity squamous cell carcinoma (OCSCC) after tumor resection and reconstruction with tissue transfer is challenging. We compared contrast-enhanced computed tomography (ceCT), 18 F-fluorodeoxyglucose-positron emission tomography combined with noncontrast enhanced CT (18 F-FDG-PET/CT), and 18 F-FDG-PET combined with ceCT (18 F-FDG-PET/ceCT) to determine the accuracy for detection of residual/recurrent disease after flap reconstruction for OCSCC.
STUDY DESIGN AND METHODS: Two readers (R1, R2) retrospectively reviewed a total of 27 18 F-FDG-PET/ceCT scans in patients after resection of stage II to IV OCSCC. They recorded the presence of local persistence/recurrence (LR), lymph node metastasis, or distant metastasis independently for ceCT, 18 F-FDG-PET/CT, and 18 F-FDG-PET/ceCT. Histological workup, imaging follow-up, or clinical follow-up served as the standard of reference. Maximum standardized uptake value (SUVmax) was evaluated to discriminate between physiological uptake and LR.
RESULTS: The highest accuracy to detect LR was achieved with 18 F-FDG-PET/ceCT, with a sensitivity/specificity of 88%/89% and 88%/79% for R1 and R2, respectively, as compared to ceCT with 75%/79% for R1 and 88%/68% for R2 and 18 F-FDG-PET/CT with 88%/58% for both R1 and R2. Receiver-operating-characteristic analysis determined a cutoff value for SUVmax of 7.2, yielding a sensitivity and specificity of 75% and 94%, respectively, to distinguish LR from physiological 18 F-FDG uptake.
CONCLUSION: 18 F-FDG-PET/ceCT seems to be the most reliable tool for locoregional surveillance of OCSCC patients after resection and reconstruction.

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2 citations in Web of Science®
1 citation in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2015
Deposited On:23 Apr 2015 10:16
Last Modified:05 Apr 2016 19:13
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0023-852X
Publisher DOI:https://doi.org/10.1002/lary.25326
PubMed ID:25892275

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