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Chronic widespread pain: clinical comorbidities and psychological correlates


Burri, Andrea; Ogata, Soshiro; Vehof, Jelle; Williams, Frances Mk (2015). Chronic widespread pain: clinical comorbidities and psychological correlates. Pain, 156(8):1458-1464.

Abstract

Recent studies have provided consistent evidence for a genetic influence on chronic widespread musculoskeletal pain (CWP). The aim of this study was to investigate a) the etiological structure underlying CWP by examining the covariation between CWP and psychological comorbidities and psycho-affective correlates, and b) the decomposition of the covariation into genetic and environmental components. A total 3,266 female twins (mean age 56.6 years) were subject to multivariate analyses. Using validated questionnaires to classify twins as having CWP, the prevalence of CWP was 20.8%. In the multivariate analysis, the most suitable model was the common pathway model. This model revealed two underlying latent variables, one common to anxiety, emotional intelligence, and emotional instability (f1) and the other common to depression and CWP (f2), the latter being highly heritable (86%). Both latent variables (f1, f2) shared an additive genetic and a non-shared environmental factor. In addition, a second additive genetic factor loading only on f2 was found. This study reveals the structure of genetic and environmental influences of CWP and its psycho-affective correlates. The results show that the clustering of CWP and depression is due to a common, highly heritable, underlying latent trait. In addition, we found evidence that CWP, anxiety, emotional instability and emotional intelligence are influenced by different underlying latent traits sharing the same genetic and non-shared environmental factors. This is the first study to reveal the structure and relative importance of genetic and environmental influences on complex etiological mechanisms CWP and its correlates.

Abstract

Recent studies have provided consistent evidence for a genetic influence on chronic widespread musculoskeletal pain (CWP). The aim of this study was to investigate a) the etiological structure underlying CWP by examining the covariation between CWP and psychological comorbidities and psycho-affective correlates, and b) the decomposition of the covariation into genetic and environmental components. A total 3,266 female twins (mean age 56.6 years) were subject to multivariate analyses. Using validated questionnaires to classify twins as having CWP, the prevalence of CWP was 20.8%. In the multivariate analysis, the most suitable model was the common pathway model. This model revealed two underlying latent variables, one common to anxiety, emotional intelligence, and emotional instability (f1) and the other common to depression and CWP (f2), the latter being highly heritable (86%). Both latent variables (f1, f2) shared an additive genetic and a non-shared environmental factor. In addition, a second additive genetic factor loading only on f2 was found. This study reveals the structure of genetic and environmental influences of CWP and its psycho-affective correlates. The results show that the clustering of CWP and depression is due to a common, highly heritable, underlying latent trait. In addition, we found evidence that CWP, anxiety, emotional instability and emotional intelligence are influenced by different underlying latent traits sharing the same genetic and non-shared environmental factors. This is the first study to reveal the structure and relative importance of genetic and environmental influences on complex etiological mechanisms CWP and its correlates.

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12 citations in Web of Science®
10 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:06 Faculty of Arts > Institute of Psychology
Dewey Decimal Classification:150 Psychology
Date:4 April 2015
Deposited On:30 Apr 2015 12:04
Last Modified:08 Dec 2017 12:56
Publisher:Elsevier
ISSN:0304-3959
Publisher DOI:https://doi.org/10.1097/j.pain.0000000000000182
PubMed ID:25851458

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