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Kardiovaskuläre Stressprotektion während der Anästhesieeinleitung : Vergleich zwischen Clonidin und Esmolol


Zalunardo, M P; Zollinger, A; Szelloe, P; Spahn, D R; Seifert, Burkhardt; Pasch, T (2001). Kardiovaskuläre Stressprotektion während der Anästhesieeinleitung : Vergleich zwischen Clonidin und Esmolol. Der Anästhesist, 50(1):21-25.

Abstract

Alpha-2-adrenoceptor-agonists as well as cardioselective betareceptor-antagonists have been shown to blunt stress response due to tracheal intubation. The purpose of our study was to investigate,whether clonidine or esmolol is more efficient to attenuate stress response due to intubation.44 patients were randomly assigned to receive either clonidine (n=22; 3 microg/kg) or esmolol (n=22; 2 mg/kg) immediately prior to a standardized induction of anaesthesia. Heart rate, arterial blood pressure, cardiac output, epinephrine and norepinephrine plasma concentrations were measured before,during and 10 min after intubation. Blood pressure was measured invasively and cardiac output was determined by transthoracic echocardiography. Absolute values and increase of mean arterial pressure and norepinephrine plasma concentrations were significantly less in the clonidine group (p<0,05). Clonidine (3 microg/kg) is more efficient than esmolol (2 mg/kg) in blunting stress response due to endotracheal intubation.

Abstract

Alpha-2-adrenoceptor-agonists as well as cardioselective betareceptor-antagonists have been shown to blunt stress response due to tracheal intubation. The purpose of our study was to investigate,whether clonidine or esmolol is more efficient to attenuate stress response due to intubation.44 patients were randomly assigned to receive either clonidine (n=22; 3 microg/kg) or esmolol (n=22; 2 mg/kg) immediately prior to a standardized induction of anaesthesia. Heart rate, arterial blood pressure, cardiac output, epinephrine and norepinephrine plasma concentrations were measured before,during and 10 min after intubation. Blood pressure was measured invasively and cardiac output was determined by transthoracic echocardiography. Absolute values and increase of mean arterial pressure and norepinephrine plasma concentrations were significantly less in the clonidine group (p<0,05). Clonidine (3 microg/kg) is more efficient than esmolol (2 mg/kg) in blunting stress response due to endotracheal intubation.

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9 citations in Web of Science®
12 citations in Scopus®
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Additional indexing

Other titles:Cardiovascular stress protection following anesthesia induction. Comparison of clonidine and esmolol
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:January 2001
Deposited On:21 May 2015 10:17
Last Modified:05 Apr 2016 19:15
Publisher:Springer
ISSN:0003-2417
Publisher DOI:https://doi.org/10.1007/s001010050958
PubMed ID:11220254

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