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Modeling human liver cancer heterogeneity: virally induced transgenic models and mouse genetic models of chronic liver inflammation


Ringelhan, Marc; Reisinger, Florian; Yuan, Detian; Weber, Achim; Heikenwalder, Mathias (2014). Modeling human liver cancer heterogeneity: virally induced transgenic models and mouse genetic models of chronic liver inflammation. Current Protocols in Pharmacology, 67:14.31.1-14.31.17.

Abstract

In addition to being the most common primary liver cancer, hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in humans. Treatment options are limited for this chemoresistant cancer, with liver transplantation and surgical intervention in early stages being the most successful treatments. Drug development over the past 15 years has focused on generating mouse models that mimic the human pathology for HCC. This has enabled the laboratory testing of potentially new human therapeutics. Described in this unit are the classification of HCC and an overview of hepatitis virus-related transgenic and genetically engineered mouse models (GEMMs) that are employed for elucidating the mechanism(s) responsible for the development of HCC, with particular emphasis on genetic, dietary, and environmental factors. © 2014 by John Wiley & Sons, Inc.

Abstract

In addition to being the most common primary liver cancer, hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in humans. Treatment options are limited for this chemoresistant cancer, with liver transplantation and surgical intervention in early stages being the most successful treatments. Drug development over the past 15 years has focused on generating mouse models that mimic the human pathology for HCC. This has enabled the laboratory testing of potentially new human therapeutics. Described in this unit are the classification of HCC and an overview of hepatitis virus-related transgenic and genetically engineered mouse models (GEMMs) that are employed for elucidating the mechanism(s) responsible for the development of HCC, with particular emphasis on genetic, dietary, and environmental factors. © 2014 by John Wiley & Sons, Inc.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2014
Deposited On:03 Jun 2015 15:06
Last Modified:14 Feb 2018 23:29
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1934-8282
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/0471141755.ph1431s67
PubMed ID:25446288

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