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Absence of BRAF gene mutations differentiates spitz nevi from malignant melanoma


Mihic-Probst, Daniela; Perren, Aurel; Schmid, Sonja; Saremaslani, Parvin; Komminoth, Paul; Heitz, Philipp U (2004). Absence of BRAF gene mutations differentiates spitz nevi from malignant melanoma. Anticancer Research, 24(4):2415-2418.

Abstract

BACKGROUND: Distinction of Spitz nevus from malignant melanoma is sometimes difficult on the basis of conventional histology. A high rate of BRAF gene mutations in malignant melanomas (66%) and nevi (82%) has recently been reported.
MATERIALS AND METHODS: We screened a series of 20 Spitz nevi for BRAF mutations in exons 11 and 15 by denaturing gradient gel electrophoresis (DGGE).
RESULTS: BRAF mutations could not be identified in Spitz nevi.
CONCLUSION: Our results show that mutations within the BRAF gene are useful markers for the differential diagnosis between Spitz nevus and malignant melanoma.

Abstract

BACKGROUND: Distinction of Spitz nevus from malignant melanoma is sometimes difficult on the basis of conventional histology. A high rate of BRAF gene mutations in malignant melanomas (66%) and nevi (82%) has recently been reported.
MATERIALS AND METHODS: We screened a series of 20 Spitz nevi for BRAF mutations in exons 11 and 15 by denaturing gradient gel electrophoresis (DGGE).
RESULTS: BRAF mutations could not be identified in Spitz nevi.
CONCLUSION: Our results show that mutations within the BRAF gene are useful markers for the differential diagnosis between Spitz nevus and malignant melanoma.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:July 2004
Deposited On:22 Jul 2015 06:32
Last Modified:05 Apr 2016 19:18
Publisher:International Institute of Anticancer Research
ISSN:0250-7005
Free access at:PubMed ID. An embargo period may apply.
PubMed ID:15330192

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