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Successful outcome of severe adenovirus hepatitis of the allograft following liver transplantation


Perez, D; McCormack, L; Petrowsky, H; Jochum, W; Mullhaupt, B; Clavien, P-A (2007). Successful outcome of severe adenovirus hepatitis of the allograft following liver transplantation. Transplant Infectious Disease, 9(4):318-322.

Abstract

Here we report the first adult patient who survived severe adenoviral hepatitis of a liver graft, in contrast to 4 previously reported cases in adults, all of which had a fatal outcome. Early diagnosis was based on the immunohistological detection of adenoviral protein in the context of biopsy-proven hepatitis. Dramatic reduction of immunosuppression along with supportive care were the treatment strategies in this case. Adenoviral infection of the allograft should always be considered as a differential diagnosis when clinical signs of severe hepatitis are present after liver transplantation. Accurate diagnosis with immunohistochemical detection of viral proteins in the liver graft is of paramount importance for the early diagnosis and management of this uncommon, severe, and probably underdiagnosed entity.

Abstract

Here we report the first adult patient who survived severe adenoviral hepatitis of a liver graft, in contrast to 4 previously reported cases in adults, all of which had a fatal outcome. Early diagnosis was based on the immunohistological detection of adenoviral protein in the context of biopsy-proven hepatitis. Dramatic reduction of immunosuppression along with supportive care were the treatment strategies in this case. Adenoviral infection of the allograft should always be considered as a differential diagnosis when clinical signs of severe hepatitis are present after liver transplantation. Accurate diagnosis with immunohistochemical detection of viral proteins in the liver graft is of paramount importance for the early diagnosis and management of this uncommon, severe, and probably underdiagnosed entity.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:December 2007
Deposited On:24 Jul 2015 10:32
Last Modified:05 Apr 2016 19:19
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:1398-2273
Publisher DOI:https://doi.org/10.1111/j.1399-3062.2007.00205.x
PubMed ID:17605750

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