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Density gradients at hydrogel interfaces for enhanced cell penetration


Simona, B R; Hirt, L; Demkó, L; Zambelli, T; Vörös, J; Ehrbar, M; Milleret, V (2015). Density gradients at hydrogel interfaces for enhanced cell penetration. Biomaterials Science, 3(4):586-591.

Abstract

We report that stiffness gradients facilitate infiltration of cells through otherwise cell-impermeable hydrogel interfaces. By enabling the separation of hydrogel manufacturing and cell seeding, and by improving cell colonization of additively manufactured hydrogel elements, interfacial density gradients present a promising strategy to progress in the creation of 3D tissue models.

Abstract

We report that stiffness gradients facilitate infiltration of cells through otherwise cell-impermeable hydrogel interfaces. By enabling the separation of hydrogel manufacturing and cell seeding, and by improving cell colonization of additively manufactured hydrogel elements, interfacial density gradients present a promising strategy to progress in the creation of 3D tissue models.

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5 citations in Web of Science®
4 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Obstetrics
04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:17 April 2015
Deposited On:22 Dec 2015 16:09
Last Modified:05 Apr 2016 19:20
Publisher:RSC Publishing
ISSN:2047-4830
Publisher DOI:https://doi.org/10.1039/c4bm00416g
PubMed ID:26222418

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