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Quantitative EEG analysis in early onset Alzheimer's disease: correlations with severity, clinical characteristics, visual EEG and CCT.


Schreiter-Gasser, Ursula; Gasser, Theo; Ziegler, Peter (1994). Quantitative EEG analysis in early onset Alzheimer's disease: correlations with severity, clinical characteristics, visual EEG and CCT. Electroencephalography and Clinical Neurophysiology, 90(4):267-72.

Abstract

We report EEG findings in 15 presenile Alzheimer patients (probable Alzheimer's disease according to NINCDS-ADRDA criteria) in relation to clinical characteristics. The quantitative EEG was analysed in terms of absolute band power while accounting for EOG and EMG artifacts, respectively. The degree of dementia is strongly reflected by an increase of power in the delta frequency band, accentuated on the left hemisphere, as well as decrease of alpha activity. Longer duration of disease is associated with a decrease of power in the alpha frequency band, earlier age at onset with an additional increase of power in the theta frequency band. Visual EEG evaluation correlates highly with the degree of dementia, in contrast to visually assessed CCT.

Abstract

We report EEG findings in 15 presenile Alzheimer patients (probable Alzheimer's disease according to NINCDS-ADRDA criteria) in relation to clinical characteristics. The quantitative EEG was analysed in terms of absolute band power while accounting for EOG and EMG artifacts, respectively. The degree of dementia is strongly reflected by an increase of power in the delta frequency band, accentuated on the left hemisphere, as well as decrease of alpha activity. Longer duration of disease is associated with a decrease of power in the alpha frequency band, earlier age at onset with an additional increase of power in the theta frequency band. Visual EEG evaluation correlates highly with the degree of dementia, in contrast to visually assessed CCT.

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Additional indexing

Item Type:Journal Article, not refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:April 1994
Deposited On:19 Aug 2015 12:41
Last Modified:05 Apr 2016 19:21
Publisher:Elsevier
ISSN:0013-4694
Publisher DOI:https://doi.org/10.1016/0013-4694(94)90144-9
PubMed ID:7512907

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