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Determination of kidney function in patients with ovarian cancer treated with chemotherapy: calculation versus measurement of creatine clearance


Küng, F; Köchli, O R; Seifert, Burkhardt; Haller, U (1994). Determination of kidney function in patients with ovarian cancer treated with chemotherapy: calculation versus measurement of creatine clearance. Gynäkologisch-geburtshilfliche Rundschau, 34(3):157-161.

Abstract

In patients with ovarian cancer receiving chemotherapy we compared the creatinine clearance measured in the usual way with the calculation of the creatinine clearance according to the formulas of Jelliffe and Cockroft. Regression analysis only showed a moderate correlation, whereas the analysis of the data by ROC curves allows the use of these formulas as screening tests with acceptable values of sensitivity and false-positive rate. Therefore, in the majority of these patients, collecting urine over 24 h before starting chemotherapy is no longer necessary.

Abstract

In patients with ovarian cancer receiving chemotherapy we compared the creatinine clearance measured in the usual way with the calculation of the creatinine clearance according to the formulas of Jelliffe and Cockroft. Regression analysis only showed a moderate correlation, whereas the analysis of the data by ROC curves allows the use of these formulas as screening tests with acceptable values of sensitivity and false-positive rate. Therefore, in the majority of these patients, collecting urine over 24 h before starting chemotherapy is no longer necessary.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:1994
Deposited On:15 Oct 2015 14:19
Last Modified:05 Apr 2016 19:26
Publisher:Karger
ISSN:1018-8843
PubMed ID:7987083

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