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Adeno-associated virus type 2 Rep68 can bind to consensus rep-binding sites on the herpes simplex virus 1 genome


Seyffert, Michael; Glauser, Daniel L; Tobler, Kurt; Georgiev, Oleg; Vogel, Rebecca; Vogt, Bernd; Agundez, Leticia; Linden, Michael; Büning, Hildegard; Ackermann, Mathias; Fraefel, Cornel (2015). Adeno-associated virus type 2 Rep68 can bind to consensus rep-binding sites on the herpes simplex virus 1 genome. Journal of Virology, 89(21):11150-11158.

Abstract

Adeno-associated virus type 2 is known to inhibit replication of herpes simplex virus 1 (HSV-1). This activity has been linked to the helicase- and DNA-binding domains of the Rep68/Rep78 proteins. Here, we show that Rep68 can bind to consensus Rep-binding sites on the HSV-1 genome and that the Rep helicase activity can inhibit replication of any DNA if binding is facilitated. Therefore, we hypothesize that inhibition of HSV-1 replication involves direct binding of Rep68/Rep78 to the HSV-1 genome.

Abstract

Adeno-associated virus type 2 is known to inhibit replication of herpes simplex virus 1 (HSV-1). This activity has been linked to the helicase- and DNA-binding domains of the Rep68/Rep78 proteins. Here, we show that Rep68 can bind to consensus Rep-binding sites on the HSV-1 genome and that the Rep helicase activity can inhibit replication of any DNA if binding is facilitated. Therefore, we hypothesize that inhibition of HSV-1 replication involves direct binding of Rep68/Rep78 to the HSV-1 genome.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Virology
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:2015
Deposited On:16 Oct 2015 10:28
Last Modified:14 Feb 2018 09:34
Publisher:American Society for Microbiology
ISSN:0022-538X
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1128/JVI.01370-15
PubMed ID:26292324

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