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Nalmefen und Opioid-Entzugssyndrom: systematische Analyse der globalen Pharmacovigilance Datenbank


Dahmke, H; Kupferschmidt, H; Kullak-Ublick, G A; Weiler, S (2015). Nalmefen und Opioid-Entzugssyndrom: systematische Analyse der globalen Pharmacovigilance Datenbank. Praxis, 2015(104):1129-1134.

Abstract

Nalmefene (Selincro®) is a selective opioid receptor antagonist, which was licensed in April 2014 in Switzerland for the reduction of alcohol consumption in adults with a high drinking risk level. 200 reports of adverse drug reactions of nalmefene have been documented worldwide in the WHO global pharmacovigilance database between 07.03.1997 to 01.03.2015. In 21 cases (10.5%) nalmefene and an opioid were administered concomitantly, causing withdrawal symptoms. Until now, the regional pharmacovigilance center in Zurich received four cases of nalmefene combined with opioids. This combination should be avoided.

Abstract

Nalmefene (Selincro®) is a selective opioid receptor antagonist, which was licensed in April 2014 in Switzerland for the reduction of alcohol consumption in adults with a high drinking risk level. 200 reports of adverse drug reactions of nalmefene have been documented worldwide in the WHO global pharmacovigilance database between 07.03.1997 to 01.03.2015. In 21 cases (10.5%) nalmefene and an opioid were administered concomitantly, causing withdrawal symptoms. Until now, the regional pharmacovigilance center in Zurich received four cases of nalmefene combined with opioids. This combination should be avoided.

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Additional indexing

Other titles:Nalmefene and opioid withdrawal syndrome: analysis of the global pharmacovigilance database for adverse drug reactions
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Clinical Pharmacology and Toxicology
Dewey Decimal Classification:610 Medicine & health
Language:German
Date:2015
Deposited On:21 Oct 2015 14:52
Last Modified:01 Nov 2016 01:00
Publisher:Hans Huber
ISSN:1661-8157
Additional Information:Diese Artikelfassung entspricht nicht vollständig dem in der Zeitschrift veröffentlichten Artikel. Dies ist nicht die Originalversion des Artikels und kann daher nicht zur Zitierung herangezogen werden.
Publisher DOI:https://doi.org/10.1024/1661-8157/a002160
PubMed ID:26463904

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